A0A1D8P3W9 · A0A1D8P3W9_9FLAO
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids291 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Urechidicola
Accessions
- Primary accessionA0A1D8P3W9
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-119 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | ||||
Sequence: LDGKKTSSDIKIEIAEEVKKIKAQGKKTPHLAAVLVGTDGASMTYVGAKVKACELVGFESTLIELPEDTTEEKLLNEIEILNIDNEIDGFIVQLPLPKHIDEQKVLMAINPDKDVD | ||||||
Domain | 122-288 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | ||||
Sequence: HPTNVGRMTLDLPSFIPATPFGIMELLERYKVETSGANVVVIGRSHIVGRPMSILMSQKRPAGDATVTVAHSRTKNLPEITKKADIIIAALGIPEFLTGDMVKDQVTVIDVGITRVDDVSKKRGYRLAGDVHFESVSKKASFITPVPGGVGPMTIAMLLKNTLLACS |
Sequence similarities
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length291
- Mass (Da)31,569
- Last updated2017-01-18 v1
- ChecksumD4E6B5B38B5EB6C8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017478 EMBL· GenBank· DDBJ | AOW19290.1 EMBL· GenBank· DDBJ | Genomic DNA |