A0A1D8MRK0 · A0A1D8MRK0_9EURY

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

Features

Showing features for binding site.

121820406080100120140160180200
TypeIDPosition(s)Description
Binding site7a divalent metal cation (UniProtKB | ChEBI)
Binding site8a divalent metal cation (UniProtKB | ChEBI)
Binding site103a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribonuclease H2 complex
Molecular Functionmanganese ion binding
Molecular FunctionRNA binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer
Biological Processmismatch repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease HII
  • EC number
  • Short names
    RNase HII

Gene names

    • Name
      rnhB
    • ORF names
      AQV86_01800

Organism names

Accessions

  • Primary accession
    A0A1D8MRK0

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-212RNase H type-2

Sequence similarities

Belongs to the RNase HII family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    218
  • Mass (Da)
    24,604
  • Last updated
    2017-01-18 v1
  • Checksum
    EF6A2EEB3E282BF7
MKVLGLDEAGRGPVIGSMFIGGFMAEEIDVELEDLDVKDSKKLSDSKREGLRSELGRYGDVFLKEVTASEVDELREVMSLNEIEIQAFADVIERADPDKVIIDLPEPDADRFIAKLKRELPGKFSDREFVAEHEADDEFPIVSAASIAAKSARENHIEELHQKYGYDFKSGYPHDKPTIKFLETYLGEKGEMPPETRMSWSTAERIVKESSQKGLEDF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP012986
EMBL· GenBank· DDBJ
AOV94639.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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