A0A1D8MRK0 · A0A1D8MRK0_9EURY
- ProteinRibonuclease HII
- GenernhB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids218 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | ribonuclease H2 complex | |
Molecular Function | manganese ion binding | |
Molecular Function | RNA binding | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Biological Process | DNA replication, removal of RNA primer | |
Biological Process | mismatch repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonuclease HII
- EC number
- Short namesRNase HII
Gene names
Organism names
- Organism
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Candidatus Nanohaloarchaea
Accessions
- Primary accessionA0A1D8MRK0
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-212 | RNase H type-2 | ||||
Sequence: MKVLGLDEAGRGPVIGSMFIGGFMAEEIDVELEDLDVKDSKKLSDSKREGLRSELGRYGDVFLKEVTASEVDELREVMSLNEIEIQAFADVIERADPDKVIIDLPEPDADRFIAKLKRELPGKFSDREFVAEHEADDEFPIVSAASIAAKSARENHIEELHQKYGYDFKSGYPHDKPTIKFLETYLGEKGEMPPETRMSWSTAERIVKESSQ |
Sequence similarities
Belongs to the RNase HII family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length218
- Mass (Da)24,604
- Last updated2017-01-18 v1
- ChecksumEF6A2EEB3E282BF7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP012986 EMBL· GenBank· DDBJ | AOV94639.1 EMBL· GenBank· DDBJ | Genomic DNA |