A0A1D8I1N4 · A0A1D8I1N4_SOUCH
- ProteinHepatic triacylglycerol lipase
- GeneLIPC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids500 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H+This reaction proceeds in the forward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholineThis reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H+ + sn-glycero-3-phospho-L-serineThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + sn-glycerol 3-phosphocholineThis reaction proceeds in the forward direction.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | high-density lipoprotein particle | |
Molecular Function | 1-acyl-2-lysophosphatidylserine acylhydrolase activity | |
Molecular Function | apolipoprotein binding | |
Molecular Function | heparin binding | |
Molecular Function | lipoprotein lipase activity | |
Molecular Function | lysophospholipase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylserine 1-acylhydrolase activity | |
Molecular Function | phospholipase A1 activity | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | triglyceride catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameHepatic triacylglycerol lipase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Delphinidae > Sousa
Accessions
- Primary accessionA0A1D8I1N4
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MENSLCVSIFLVLCIFIQSSA | ||||||
Chain | PRO_5009107646 | 22-500 | Hepatic triacylglycerol lipase | |||
Sequence: HGQSLGLESFGRRSRAAETKETLQETRTRFLLFKEETNKGCQIRLNHSDTLQQCGFNSSLPLVMIVHGWLMEASLENWIWQMVAALKSQVARPVNVGLAEWVTLAHTHYSIAVRNTRLVGQEIAALLQWLEESVHFSPSNVHLIGYSLGAHVSGFAGSYMSRKHKVGRITGLDAAGLLFKRASPSDRLSPDDANFVDAIHTFTQEHMGLSVGIKQPIAHYDFYPNGGSYQPGCHFLELYKHIAKHGLNAITQAIKCAHERSVHLFIDSLLHADMQSTAYPCRDMDSFSQGLCLSCKKGRCNTLGYYARQEPQSKKSKSLFLVTRAQSPFKVYHYQLKIQFSNEIEKPAEPTFAMSLLGTKEEMQKIPITLNKGITSNKTYSFLITLDLDIGELIMTKFKWENSLVWSNVWNTVQTIIPWGRESLHSGLVLKSIRVKAGETQQRMTFCSENMNDLQLHPTQEKTFVRCESNSKKLKRKIR |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 353-487 | PLAT | ||||
Sequence: YHYQLKIQFSNEIEKPAEPTFAMSLLGTKEEMQKIPITLNKGITSNKTYSFLITLDLDIGELIMTKFKWENSLVWSNVWNTVQTIIPWGRESLHSGLVLKSIRVKAGETQQRMTFCSENMNDLQLHPTQEKTFVR |
Sequence similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length500
- Mass (Da)56,548
- Last updated2017-01-18 v1
- Checksum1E9226054C1F5AF7
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 500 | |||||
Sequence: R |