A0A1D8D6M0 · A0A1D8D6M0_ACACA
- Proteincytochrome-c oxidase
- Genecox1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids873 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | copper ion binding | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecytochrome-c oxidase
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Discosea > Longamoebia > Centramoebida > Acanthamoebidae > Acanthamoeba
Accessions
- Primary accessionA0A1D8D6M0
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-51 | Helical | ||||
Sequence: LYLIFGGFSGIIGTIFSMIIRL | ||||||
Transmembrane | 71-97 | Helical | ||||
Sequence: IITAHAFVMIFFFVMPVMIGGFGNWFV | ||||||
Transmembrane | 118-140 | Helical | ||||
Sequence: LLPPSLFLLLCSSLVEFGAGTGW | ||||||
Transmembrane | 160-185 | Helical | ||||
Sequence: AIFSLHLAGISSLLGAINFITTIFNM | ||||||
Transmembrane | 197-224 | Helical | ||||
Sequence: LFVWSVLITAFLLLFSLPVLAGAITMLL | ||||||
Transmembrane | 244-268 | Helical | ||||
Sequence: LYQHLFWFFGHPEVYILILPAFGIV | ||||||
Transmembrane | 280-304 | Helical | ||||
Sequence: IFGYIGMVYAMLSIAVLGFIVWAHH | ||||||
Transmembrane | 316-339 | Helical | ||||
Sequence: AYFTAATMMIAVPTGIKIFSWIAT | ||||||
Transmembrane | 351-370 | Helical | ||||
Sequence: LLFVIGFLILFTLGGLTGIV | ||||||
Transmembrane | 390-410 | Helical | ||||
Sequence: FHYVLSMGAVFAFFAGFYYWF | ||||||
Transmembrane | 422-441 | Helical | ||||
Sequence: YGNVHFWLMFIGVNLTFFPM | ||||||
Transmembrane | 461-489 | Helical | ||||
Sequence: YYWNILSSFGSIISSVSVIVFFYLIYLAF | ||||||
Transmembrane | 533-551 | Helical | ||||
Sequence: FSKFFIFFMVSLSVLFIFY | ||||||
Transmembrane | 586-605 | Helical | ||||
Sequence: ILFFLAVILFVVGYLLLSTY | ||||||
Transmembrane | 656-680 | Helical | ||||
Sequence: IIWTILPAFILLFIAVPSFALLYAM |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-496 | Cytochrome oxidase subunit I profile | ||||
Sequence: FFTDNRWLFSTNHKDIGTLYLIFGGFSGIIGTIFSMIIRLELAAPGSQILSGNSQLYNVIITAHAFVMIFFFVMPVMIGGFGNWFVPLMIGAPDMAFPRLNNISFWLLPPSLFLLLCSSLVEFGAGTGWTVYPPLSSIVAHSGGSVDLAIFSLHLAGISSLLGAINFITTIFNMRVPGLSMHKLPLFVWSVLITAFLLLFSLPVLAGAITMLLTDRNFNTSFFDPSGGGDPILYQHLFWFFGHPEVYILILPAFGIVSQIIGTFSNKSIFGYIGMVYAMLSIAVLGFIVWAHHMYTVGLDVDTRAYFTAATMMIAVPTGIKIFSWIATLWGGQIVRKTPLLFVIGFLILFTLGGLTGIVLSNAGLDIMLHDTYYVVAHFHYVLSMGAVFAFFAGFYYWFWKISGYTYNEMYGNVHFWLMFIGVNLTFFPMHFVGLAGMPRRIPDYPDNYYYWNILSSFGSIISSVSVIVFFYLIYLAFNNNNTPK | ||||||
Domain | 560-684 | Cytochrome oxidase subunit II transmembrane region profile | ||||
Sequence: HTNSWKIGFQDPTTPIAYGIIKLHDHILFFLAVILFVVGYLLLSTYKKFYYGSLNNDLPESKRISLFDTLINTYKENLSFNVTNRTYNINHGTTIEIIWTILPAFILLFIAVPSFALLYAMDEII | ||||||
Domain | 685-865 | Cytochrome oxidase subunit II copper A binding | ||||
Sequence: DPVLTVKVIGHQWYWSYEYSDYSVVYSNRMLDYDSIDRFAAMEMMYKGMGYLKDRSLLSYLYIPMVIPETTIKFDSYMIHEAELNLGDLRLLKTDMPLFLPKNTHIRLLITSSDVLHSWAVPSFGVKVDAVPGRLNQTSLYLKNTGTFYGQCSELCGVNHAFMPIEVYVVNPVYFYNYVYI |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length873
- Mass (Da)99,214
- Last updated2017-01-18 v1
- Checksum0BC820F0162B8EB3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KX580904 EMBL· GenBank· DDBJ | AOS85694.1 EMBL· GenBank· DDBJ | Genomic DNA |