A0A1D8BAT8 · A0A1D8BAT8_TMUV

Function

function

Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.

Catalytic activity

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site1549Charge relay system; for serine protease NS3 activity
Active site1573Charge relay system; for serine protease NS3 activity
Active site1633Charge relay system; for serine protease NS3 activity
Binding site2960Zn2+ 1 (UniProtKB | ChEBI)
Binding site2964Zn2+ 1 (UniProtKB | ChEBI)
Binding site2969Zn2+ 1 (UniProtKB | ChEBI)
Binding site2972Zn2+ 1 (UniProtKB | ChEBI)
Binding site3237Zn2+ 2 (UniProtKB | ChEBI)
Binding site3253Zn2+ 2 (UniProtKB | ChEBI)
Binding site3372Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Cellular Componentviral capsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functiondouble-stranded RNA binding
Molecular Functionmetal ion binding
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionprotein dimerization activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionstructural molecule activity
Biological Processfusion of virus membrane with host endosome membrane
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

Accessions

  • Primary accession
    A0A1D8BAT8

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host nucleus
Membrane
; Multi-pass membrane protein
Membrane
; Peripheral membrane protein
Secreted
Virion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane740-761Helical
Transmembrane768-788Helical
Transmembrane1139-1160Helical
Transmembrane1172-1194Helical
Transmembrane1214-1235Helical
Transmembrane1302-1323Helical
Transmembrane1335-1357Helical
Transmembrane1369-1389Helical
Transmembrane1396-1415Helical
Transmembrane2171-2189Helical
Transmembrane2196-2214Helical
Transmembrane2220-2237Helical
Transmembrane2249-2266Helical
Transmembrane2304-2322Helical
Transmembrane2329-2348Helical
Transmembrane2368-2390Helical
Transmembrane2438-2458Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond290↔317
Disulfide bond347↔403
Disulfide bond361↔392
Disulfide bond379↔408
Disulfide bond477↔575
Disulfide bond592↔623

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1368-1498Flavivirus NS2B
Domain1499-1676Peptidase S7
Domain1679-1835Helicase ATP-binding
Domain1845-2011Helicase C-terminal
Domain2521-2786MRNA cap 0-1 NS5-type MT
Domain3050-3202RdRp catalytic

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,425
  • Mass (Da)
    379,890
  • Last updated
    2017-01-18 v1
  • Checksum
    6122E5A85EF544A6
MSNKKPGRPGSGRVVNMLKRGTSRGNPLARIKRTIDGVLRGAGPIRFVLALLTFFKFTALRPTIGMLKRWKLVGVNEATKHLKSFKRDIGQMLDGLNKRKAKRRGGSCSWLIMLLPIVAGLKLGNYNGRVLATLNKTDVSDLLVIPTTAGSNGCVVRALDVGLMCQDDITYLCPKLEYGYEPEDIDCWCNETEIYIHYGRCTPSRHGRRSRRSVNVHHHGESLLEAKNTPWMDSTKATKYLTKVENWALRNPGYALAAIFIGWNLGTTRSQKIIFTIMLMLIAPAYSFSCLGMQNRDFVEGVNGVEWIDVVLEGGSCVTITAKDRPTIDVKMMNMEATELAVVRSYCYEPKVSDVTTESRCPTMGEAHNPKATYAEYICKKDFVDRGWGNGCGLFGKGSIQTCAKFDCTKKAEGRIVQKENVQFEVAVFIHGSTEASTYHNYSAQQSLKHAARFVITPKSPVYTAEMEDYGTVTLECEPRSGVDMGQFYVFTMNTKSWLVNRDWFHDLNLPWTGSSAGTWQNKESLIEFEEAHATKQSVVALASQEGALHAALAGAIPVKYSGNKLEMTSGHLKCRVKMQGLKLKGMTYPMCSNTFSLVKNPTDTGHGTVVVELSYAGADGPCRVPISMSADLNDMTPVGRLITVNPYVSTSSTGAKIMVEVEPPFGDSFILVGSGKGQIRYQWHRSGSTIGKAFTSTLKGAQRMVALGDTAWDFGSVGGVLTSIGKGIHQVFGSAFKSLFGGMSWITQGMLGALLLWMGLNARDRSISMTFLVVGGILVFLAVNVNADTGCSIDLARKELKCGQGMFVFNDVEAWKDNYKYYPSTPRRLAKVVAEAHEAGICGIRSVSRLEHNMWVSIKHELNAILEDNAIDLTVVVEENPGRYRKTNQRLPNVDGELTYGWKKWGKSIFSSPKMSNNTFVIDGPKTRECPDERRAWNSMKIEDFGFGVLSTKVWMEMRTENTTDCDTAVMGTAIKGNRAVHSDLSYWIESKNNGSWKLERAVLGEVKSCTWPETHTLWSVSVVESELIIPKTLGGPKSHHNTRTGYKVQSSGPWDEKEIVIDFDYCPGTTVTVTSSCRDRGPSARTTTASGKLITDWCCRSCTIPPLRFVTKSGCWYGMEIRPIVHGDDMLIKSKVMAFQGGGMEPMQLGMLVMIVAAQEILRRRMTAPIAWSALLLLMALVLFGGITYSDLVKYVILVAAAFAESNTGGDIVHLAMVAAFNIQPGLLIGFLLRRKWSNQESRLLGVALALITVAMRDLNMSIPTLLNSGAMAWLLLRAVFEGTVSSFALPLVSLLAPGLRIVGIDVVRIGVLTLGILSLLKERSNAMAKKKGGMLLGVACATAGIASPLVFAGLHMVLKPVTRRGWPVSEALTAVGLTFALAGGIAQFDDSSMAIPLAVGGIMLVVAVVTGFSTDLWLEKASDISWSEEARVTGASQRFDVEIDQDGNMRLLNDPGVSLGVWAFRTGLILLSSYNPYFLPLTLAGYWMTTKAKQRGGVIWDVPAPKERKRAEVGNGVFRIMARGLLGKYQAGVGVMHEGVFHTMWHVTNGAVIQAGEGTLVPYWASVRNDLISYGGPWKLGKQWNGVDEVQVIVVQPGKEVINVQTQPGIFKTQYGEVGAVSLDYPTGTSGSPIIDKEGQVVGLYGNGILVGSGDFVSMITQGEKKEEEVPQVFDENMLRKRQLTVLDLHPGSGKTRKVLPMILKSAIDKRLRTAVLAPTRVVAAEIAEALKGLPIRYLTPAVKREHTGTEIIDVMCHATLTARLLTPQRVPNYNLFIMDEAHFTDPASIAARGYISTKVELGEAAAIFMTATPPGTTEAFPDSNSPITDIEEQIPDRAWNSGYEWITDFQGKTVWFVPSVKSGNEIAVCLTKAGKRVIQLNRKSFDSEYPKCKSGEWDFVITTDISEMGANFGAQRVIDSRKCIKPVIIEDGEGSVQMNGPVPITSASAAQRRGRVGRDVTQIGDEYHYSGPTSEDDHDFAHWKEAKILLDNINMPDGLVAQLYGPERDKVDAIDGEFRLRTEQRKHFVEYLRTGDLPVWISYKVAEAGISYNDRRWCFDGPSCNTVLEDNNPVELWTKSGEKKILKPRWRDGRLWADHQALKAFKDFASGKRSAIGILEVFRMLPDHFAHRMTESMDNIYMLTTAEKGSRAHREALEELPETLETFLLVFMMTVASMGVFLFFVQRRGLGKTGLGAMVMATVTVLLWIAEVPAQKIAGVLLVSLLLMIVLIPEPERQRSQTDSHLAVFMIVVLLVVGAVASNEMGWLEQTKKDLSALFGRKSDGHQETWGMPWPDLRPATAWAAYAGATTFLTPLLKHLIITEYVNFSLMAMTAQAGALFGLGKGMPFVKADLSVPLLLLGCWGQFTMTTTVSAVVMVILHYAFLVPGWQAEAMRSAQRRTAAGVMKNPVVDGIVATDVPDLEASTPITEKKLGQCVLVGIALVAVFLTPNTLTLTEFGMLTSAASVTLIEGAAGRIWNATTAVAMCHLLRKNWLAGASLAWTITRNLQAGTLRRGGGTGRTLGEAWKAQLNQLTRQEFMEYRKDGIIEVDRAAAKRARREGNVTGGHPVSRGTAKLRWLVERGFLKPRGKVVDLGCGRGGWSYYCATLKQVQEVRGYTKGGPGHEEPVMTQSYGWNIVTLKSGVNVHFKPTEPSDTLLCDIGEASPVPEIESARTIRVLQMVEEWLARGVEEFCIKVLCPYMPAVIKELERLQLKWGGGLVRVPLSRNSTHEMYWVSGSSGNVTNSINTVSQMLINRMHKTNRNGPRYEEDVDLGSGTRAVSCTRQRTDWGMVADRVKNLAREYAPSWHYDQDNPYKTWNYHGSYEVKATGSASSMVNGVVRILSKPWDTLQNVVNMAMTDTTPFGQQRVFKEKVDTKAPEPPAGTARVMNIVARWMWNFVGRNKQPRMCTKEEFIEKVNSNAALGAMFEEQHKWASAREAVEDPEFWSLVDRERELHLQGKCETCIYNMMGKREKKMGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMSRENTKGGVEGLGLQKLGYVLRDISAKEGGLMYADDTAGWDTRITKADLENEAIILEKMEPMHRAVAEPLIKFAYMNKVVKVMRPGRDGKTVMDVISREDQRGSGQVVTYALNTFTNLCVQLIRCMEGEELLLPEETERLKKGKEKRIQEWLQKNGENRLSAMAVSGDDCVVKPADDRFATALHFLNSMSKVRKDTQEWKPSTGWRNWQEVPFCSHHFHELQMKDGRKIVVPCRDQDELIGRARLSPGSGWSLTETACLSKAYAQMWLLMYFHRRDLRLMANAICSSVPVSWVPTGRTTWSIHGKGEWMTSEDMLAVWNRVWIEENEHMEDKTPVNSWNEVPYLGKREDGWCGSLIGHRARSTWAENIYTPIMQIRALIGPEHYVDYMPTLNRFKPIESWSEGVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX686575
EMBL· GenBank· DDBJ
AOS50834.1
EMBL· GenBank· DDBJ
Genomic RNA

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