A0A1D8BAT8 · A0A1D8BAT8_TMUV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3425 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1549 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1573 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1633 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2960 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2964 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2969 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2972 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3237 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3253 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3372 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus tembusu
- Virus hosts
Accessions
- Primary accessionA0A1D8BAT8
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 740-761 | Helical | ||||
Sequence: LFGGMSWITQGMLGALLLWMGL | ||||||
Transmembrane | 768-788 | Helical | ||||
Sequence: ISMTFLVVGGILVFLAVNVNA | ||||||
Transmembrane | 1139-1160 | Helical | ||||
Sequence: MAFQGGGMEPMQLGMLVMIVAA | ||||||
Transmembrane | 1172-1194 | Helical | ||||
Sequence: IAWSALLLLMALVLFGGITYSDL | ||||||
Transmembrane | 1214-1235 | Helical | ||||
Sequence: IVHLAMVAAFNIQPGLLIGFLL | ||||||
Transmembrane | 1302-1323 | Helical | ||||
Sequence: LRIVGIDVVRIGVLTLGILSLL | ||||||
Transmembrane | 1335-1357 | Helical | ||||
Sequence: GGMLLGVACATAGIASPLVFAGL | ||||||
Transmembrane | 1369-1389 | Helical | ||||
Sequence: WPVSEALTAVGLTFALAGGIA | ||||||
Transmembrane | 1396-1415 | Helical | ||||
Sequence: MAIPLAVGGIMLVVAVVTGF | ||||||
Transmembrane | 2171-2189 | Helical | ||||
Sequence: FLLVFMMTVASMGVFLFFV | ||||||
Transmembrane | 2196-2214 | Helical | ||||
Sequence: KTGLGAMVMATVTVLLWIA | ||||||
Transmembrane | 2220-2237 | Helical | ||||
Sequence: KIAGVLLVSLLLMIVLIP | ||||||
Transmembrane | 2249-2266 | Helical | ||||
Sequence: HLAVFMIVVLLVVGAVAS | ||||||
Transmembrane | 2304-2322 | Helical | ||||
Sequence: ATAWAAYAGATTFLTPLLK | ||||||
Transmembrane | 2329-2348 | Helical | ||||
Sequence: YVNFSLMAMTAQAGALFGLG | ||||||
Transmembrane | 2368-2390 | Helical | ||||
Sequence: WGQFTMTTTVSAVVMVILHYAFL | ||||||
Transmembrane | 2438-2458 | Helical | ||||
Sequence: LGQCVLVGIALVAVFLTPNTL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 290↔317 | |||||
Sequence: CLGMQNRDFVEGVNGVEWIDVVLEGGSC | ||||||
Disulfide bond | 347↔403 | |||||
Sequence: CYEPKVSDVTTESRCPTMGEAHNPKATYAEYICKKDFVDRGWGNGCGLFGKGSIQTC | ||||||
Disulfide bond | 361↔392 | |||||
Sequence: CPTMGEAHNPKATYAEYICKKDFVDRGWGNGC | ||||||
Disulfide bond | 379↔408 | |||||
Sequence: CKKDFVDRGWGNGCGLFGKGSIQTCAKFDC | ||||||
Disulfide bond | 477↔575 | |||||
Sequence: CEPRSGVDMGQFYVFTMNTKSWLVNRDWFHDLNLPWTGSSAGTWQNKESLIEFEEAHATKQSVVALASQEGALHAALAGAIPVKYSGNKLEMTSGHLKC | ||||||
Disulfide bond | 592↔623 | |||||
Sequence: CSNTFSLVKNPTDTGHGTVVVELSYAGADGPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1368-1498 | Flavivirus NS2B | ||||
Sequence: GWPVSEALTAVGLTFALAGGIAQFDDSSMAIPLAVGGIMLVVAVVTGFSTDLWLEKASDISWSEEARVTGASQRFDVEIDQDGNMRLLNDPGVSLGVWAFRTGLILLSSYNPYFLPLTLAGYWMTTKAKQR | ||||||
Domain | 1499-1676 | Peptidase S7 | ||||
Sequence: GGVIWDVPAPKERKRAEVGNGVFRIMARGLLGKYQAGVGVMHEGVFHTMWHVTNGAVIQAGEGTLVPYWASVRNDLISYGGPWKLGKQWNGVDEVQVIVVQPGKEVINVQTQPGIFKTQYGEVGAVSLDYPTGTSGSPIIDKEGQVVGLYGNGILVGSGDFVSMITQGEKKEEEVPQV | ||||||
Domain | 1679-1835 | Helicase ATP-binding | ||||
Sequence: ENMLRKRQLTVLDLHPGSGKTRKVLPMILKSAIDKRLRTAVLAPTRVVAAEIAEALKGLPIRYLTPAVKREHTGTEIIDVMCHATLTARLLTPQRVPNYNLFIMDEAHFTDPASIAARGYISTKVELGEAAAIFMTATPPGTTEAFPDSNSPITDIE | ||||||
Domain | 1845-2011 | Helicase C-terminal | ||||
Sequence: SGYEWITDFQGKTVWFVPSVKSGNEIAVCLTKAGKRVIQLNRKSFDSEYPKCKSGEWDFVITTDISEMGANFGAQRVIDSRKCIKPVIIEDGEGSVQMNGPVPITSASAAQRRGRVGRDVTQIGDEYHYSGPTSEDDHDFAHWKEAKILLDNINMPDGLVAQLYGPE | ||||||
Domain | 2521-2786 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: GGGTGRTLGEAWKAQLNQLTRQEFMEYRKDGIIEVDRAAAKRARREGNVTGGHPVSRGTAKLRWLVERGFLKPRGKVVDLGCGRGGWSYYCATLKQVQEVRGYTKGGPGHEEPVMTQSYGWNIVTLKSGVNVHFKPTEPSDTLLCDIGEASPVPEIESARTIRVLQMVEEWLARGVEEFCIKVLCPYMPAVIKELERLQLKWGGGLVRVPLSRNSTHEMYWVSGSSGNVTNSINTVSQMLINRMHKTNRNGPRYEEDVDLGSGTRA | ||||||
Domain | 3050-3202 | RdRp catalytic | ||||
Sequence: GLMYADDTAGWDTRITKADLENEAIILEKMEPMHRAVAEPLIKFAYMNKVVKVMRPGRDGKTVMDVISREDQRGSGQVVTYALNTFTNLCVQLIRCMEGEELLLPEETERLKKGKEKRIQEWLQKNGENRLSAMAVSGDDCVVKPADDRFATA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,425
- Mass (Da)379,890
- Last updated2017-01-18 v1
- Checksum6122E5A85EF544A6