A0A1D6YDC7 · A0A1D6YDC7_9RODE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      CoxI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Calomyscidae > Calomyscinae > Calomyscus

Accessions

  • Primary accession
    A0A1D6YDC7

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-55Helical
Transmembrane76-100Helical
Transmembrane120-143Helical
Transmembrane155-182Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-203Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    203
  • Mass (Da)
    21,598
  • Last updated
    2017-01-18 v1
  • Checksum
    F0EDDDEC792F84F5
VGTALSILIRAELGQPGALLGDDQIYNVVVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILY

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue203

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT878542
EMBL· GenBank· DDBJ
AMQ22868.1
EMBL· GenBank· DDBJ
Genomic DNA
KT878543
EMBL· GenBank· DDBJ
AMQ22869.1
EMBL· GenBank· DDBJ
Genomic DNA
KT878544
EMBL· GenBank· DDBJ
AMQ22870.1
EMBL· GenBank· DDBJ
Genomic DNA
KT878545
EMBL· GenBank· DDBJ
AMQ22871.1
EMBL· GenBank· DDBJ
Genomic DNA
KT878546
EMBL· GenBank· DDBJ
AMQ22872.1
EMBL· GenBank· DDBJ
Genomic DNA
KT878547
EMBL· GenBank· DDBJ
AMQ22873.1
EMBL· GenBank· DDBJ
Genomic DNA
KT878548
EMBL· GenBank· DDBJ
AMQ22874.1
EMBL· GenBank· DDBJ
Genomic DNA
KT878550
EMBL· GenBank· DDBJ
AMQ22876.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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