A0A1D6Y6W5 · A0A1D6Y6W5_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2943 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Protein has several cofactor binding sites:
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus
Accessions
- Primary accessionA0A1D6Y6W5
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Single-pass type I membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Membrane ; Single-pass type I membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 698-723 | Helical | ||||
Sequence: WAVFFLLLLMDAKVCAILWFCLCLAL | ||||||
Transmembrane | 735-758 | Helical | ||||
Sequence: LIALSYIADDSLFYALLFYCIIYF | ||||||
Transmembrane | 770-789 | Helical | ||||
Sequence: VYYWKFSLAFMVLALPHRAW | ||||||
Transmembrane | 796-819 | Helical | ||||
Sequence: AVTAAFSIALFCLYITCLSCYKRL | ||||||
Transmembrane | 852-880 | Helical | ||||
Sequence: LAFALCFSFLYPSLFRSIYLPLAVVCGSF | ||||||
Transmembrane | 1640-1665 | Helical | ||||
Sequence: AWVIAGGCVAALVAVAALTGSVAIIA | ||||||
Transmembrane | 2925-2942 | Helical | ||||
Sequence: WIPLLLLLPLLAAILYFN |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-84 | Disordered | ||||
Sequence: MGNNSKNQKPKPQRGPRNRVRGQSRSGPVVFPSGAVLVGGRYIPPPKKAIRGPRRGLVQAPKSSERGSPRKKRQPPPQTDSSWR | ||||||
Domain | 884-1007 | Peptidase C18 | ||||
Sequence: NKRVQKIQYLRRAEVLVRVLTICRDVYGSKWVQWCVLWVASHFGTFLYDHLTPIDTWAAPGLRDLMHSLEPITLSPMERKVVKWGARKVACGDILHGLPVSARLGREICLGPADRLTSKGWRLL | ||||||
Domain | 1008-1189 | Peptidase S29 | ||||
Sequence: SPITATVTKTRGMPSALVCCLTGRDKYPHRGHCYILTSLTKTFMGTVCKGVLWSVHHGGGTATLASDKSSLLQVLCSPGDDLVAWPAPAGSKSFQPCTCGSADVYLVTRTGQVVPARKTSEKDASLISPLPISSLKGSSGGPVLCKDGDLVGIFCSASVTRGVAKRIHFADMRTRSVSSCPP | ||||||
Domain | 1198-1350 | Helicase ATP-binding | ||||
Sequence: PAVPSSYQVSFLHAPTGSGKSTKMPLSYVELGYHVLVLNPSVASTLSFGPYMDKTYGECPNIRTGASCKTTGSKLTYSTYGKFLADGGVSAGAYDIIICDECHSTDSTSVLGIGSVLDGAESKGVKLVVLATATPPGSQTVPHPNIDEEALTQ | ||||||
Domain | 1360-1520 | Helicase C-terminal | ||||
Sequence: MLKSSLLLSGRHLIFCHSKKKCEEVALLLRKAGANAVTYYRGLDVSVIPNEGNVVVVATDALMTGYSGNFDTVTDCNTAVELDIEFSLDPTFSMVTTPKPSDAVCRTQRRGRTGRGRRGTYYYVNSGERPSGVLSSSVLCECYDSGLAWFGLSPAQVTVLL | ||||||
Region | 2169-2207 | Disordered | ||||
Sequence: RGRTVDVESSSGSELSAVSRGAASRVSEEHEMQGGPVRP | ||||||
Region | 2243-2356 | Disordered | ||||
Sequence: SGSEGEHSRESVVAPDNDQVVVAEPPPPPGPAWMRKDYVPALVSGCPIKPGSATPEPSEPSATESAPTEEKEEPKVDDPGTETDPDMPPLEGEEPEGEDDGEWETTSEKAESCS | ||||||
Compositional bias | 2307-2324 | Basic and acidic residues | ||||
Sequence: SAPTEEKEEPKVDDPGTE | ||||||
Compositional bias | 2329-2347 | Acidic residues | ||||
Sequence: MPPLEGEEPEGEDDGEWET | ||||||
Domain | 2567-2685 | RdRp catalytic | ||||
Sequence: PMGFSYDTKCFDSTVTPHDIDTERDIFLSANLPDEAKTVIKNLTSRLYRGSPMYNSRGDLVGKRECRASGVFPTSMGNTLTNFIKATAAAKAAGLSDPQFLICGDDLICITSSKGVEED |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,943
- Mass (Da)322,960
- Last updated2017-01-18 v1
- ChecksumBBA930196F079B2B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 2307-2324 | Basic and acidic residues | ||||
Sequence: SAPTEEKEEPKVDDPGTE | ||||||
Compositional bias | 2329-2347 | Acidic residues | ||||
Sequence: MPPLEGEEPEGEDDGEWET |