A0A1D6Y6W5 · A0A1D6Y6W5_9FLAV

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell lipid droplet
Cellular Componenthost cell mitochondrion
Cellular Componenthost cell nucleus
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentlipid droplet
Cellular Componentmembrane
Cellular Componentribonucleoprotein complex
Cellular Componentviral envelope
Cellular Componentviral nucleocapsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functionchannel activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionstructural molecule activity
Molecular Functionzinc ion binding
Biological Processapoptotic process
Biological Processfusion of virus membrane with host endosome membrane
Biological Processinduction by virus of host autophagy
Biological Processmonoatomic ion transmembrane transport
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
Biological Processsymbiont-mediated suppression of host TRAF-mediated signal transduction
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processtransformation of host cell by virus
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R09-250
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus

Accessions

  • Primary accession
    A0A1D6Y6W5

Subcellular Location

Cytoplasm
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Single-pass type I membrane protein
Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Single-pass type I membrane protein
Host lipid droplet
Host mitochondrion
Host nucleus
Lipid droplet
Membrane
; Multi-pass membrane protein
Membrane
; Peripheral membrane protein
Membrane
; Single-pass type I membrane protein
Mitochondrion
Virion membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane698-723Helical
Transmembrane735-758Helical
Transmembrane770-789Helical
Transmembrane796-819Helical
Transmembrane852-880Helical
Transmembrane1640-1665Helical
Transmembrane2925-2942Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-84Disordered
Domain884-1007Peptidase C18
Domain1008-1189Peptidase S29
Domain1198-1350Helicase ATP-binding
Domain1360-1520Helicase C-terminal
Region2169-2207Disordered
Region2243-2356Disordered
Compositional bias2307-2324Basic and acidic residues
Compositional bias2329-2347Acidic residues
Domain2567-2685RdRp catalytic

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,943
  • Mass (Da)
    322,960
  • Last updated
    2017-01-18 v1
  • Checksum
    BBA930196F079B2B
MGNNSKNQKPKPQRGPRNRVRGQSRSGPVVFPSGAVLVGGRYIPPPKKAIRGPRRGLVQAPKSSERGSPRKKRQPPPQTDSSWRKYLPKFWGDRGYPWPYIDPVLQWSAWGTSPGAYRTRWGPRDPRHKSRNLGRIIDTLTCGVADIAGYVPVVGAPAGALCRGAAHLVRFVEDGANFITGNIPGMGFSIFLLALLSALSCGEASVLRGGGHVVSNDCNSSQILWAASDWAIHEVGCVPCVDSTCWVPLTSSISVRNESVIVTGLGSHIDVLSAMASVCSTLGIGEACGTATLTYITFLSRFFLALNLTNDCECFLYPGAISTFEFTMRALQSMMPNLSGFVSMFSGLPNTLFTIFTNGHWGVILALCLYGTTNNYFKLCLLLLAYSALVSCETDYINVSLSCNFTVKQMWGWTFFPKWALLNGQRLNCTEGSPYNPKCKGPMDFNATTDPVVSYSGTRSHPPCPYHVSRPCSILNASRVCGKPTCFGPAPIEVGITDRDGKLASWNDTGQFFFDLRSPHRPPRGRWYGCVWLNSTGWVKQCGAPPCNMKFMSNRSKTFVCPSDCFRQNPKATYQLCGQGPWISYNCLIDYTDRYLHFPCTENFTVYPVRMMLGDGARDVRVACKFNRSSSCRTEDRLRASIVSLLYSVTTAAVPPCHFSPLPAFTTGLIHLDRNLSDVQYVWAMTPSAVNIFLRLEWAVFFLLLLMDAKVCAILWFCLCLALQAEAYLSDTVRLIALSYIADDSLFYALLFYCIIYFTPSRVPPFCVFVYYWKFSLAFMVLALPHRAWAFDNASAVTAAFSIALFCLYITCLSCYKRLFLLVKWWLEYWDVRVECAWRYLGPRVNPRDEKLAFALCFSFLYPSLFRSIYLPLAVVCGSFSMINKRVQKIQYLRRAEVLVRVLTICRDVYGSKWVQWCVLWVASHFGTFLYDHLTPIDTWAAPGLRDLMHSLEPITLSPMERKVVKWGARKVACGDILHGLPVSARLGREICLGPADRLTSKGWRLLSPITATVTKTRGMPSALVCCLTGRDKYPHRGHCYILTSLTKTFMGTVCKGVLWSVHHGGGTATLASDKSSLLQVLCSPGDDLVAWPAPAGSKSFQPCTCGSADVYLVTRTGQVVPARKTSEKDASLISPLPISSLKGSSGGPVLCKDGDLVGIFCSASVTRGVAKRIHFADMRTRSVSSCPPKYTDLDSPPAVPSSYQVSFLHAPTGSGKSTKMPLSYVELGYHVLVLNPSVASTLSFGPYMDKTYGECPNIRTGASCKTTGSKLTYSTYGKFLADGGVSAGAYDIIICDECHSTDSTSVLGIGSVLDGAESKGVKLVVLATATPPGSQTVPHPNIDEEALTQSGDIPFYGKMLKSSLLLSGRHLIFCHSKKKCEEVALLLRKAGANAVTYYRGLDVSVIPNEGNVVVVATDALMTGYSGNFDTVTDCNTAVELDIEFSLDPTFSMVTTPKPSDAVCRTQRRGRTGRGRRGTYYYVNSGERPSGVLSSSVLCECYDSGLAWFGLSPAQVTVLLQAYLKQPGLPTGLDHTEFWESVFIGLPTVDAFFLSQLKQQGVTFPYLTAIQATVCLNAQAKAPSKDERWKVLSRYITTNRTPTPLLYRLEDTHDDLTFTHPVTKYIQACMEAEIDTQTNAWVIAGGCVAALVAVAALTGSVAIIAEVHVNEKVVVVPHKGVLYADFDELEECFDHHQYIQQGYEWASRAAQKIREVATSIEPPAGQAQPMLSAIEKFWNQHMWNILSGVQYLAGLTTLPYNPSVACLMGFVSGLTTGLPRPAMAFLTILGGWAASMVAPPQAASTFVGAGLAGIAIGAVGFTDVIVGLLAGYGAGVAGALTAFKILSGVTPSGEDLINLLPSLLNPGALAVGVGAAFILKRYTGGSEGLVAWVNRLIAFCSRGNHVSPDHYVQQQQVVKDVIACLESLTLTRLVKTIHNFVTSENDQNCDFTAIYFFIQWLMKALYDCFTWAKGIILPHLPGFPIISCDTGYSGRWAGDGLVTTRCGCGNLITGNVRNEKIRITGSRKCRNVWLNAFPINSTTTGGPRPNPYDTWKTAVLRITSTEYVEFERKGTAVRVTGATADKLRIPCQVPEPDLMTFIDGVRIHRLAPSPKPMLRDEVVVLIGNHTYPVGATLPCTPEPDVDTVSSLLTDPGHVTAETAARRLRRGRTVDVESSSGSELSAVSRGAASRVSEEHEMQGGPVRPLTGEDELAWIRSFYGRSVTIEVDDKVINFDSWTINSGSEGEHSRESVVAPDNDQVVVAEPPPPPGPAWMRKDYVPALVSGCPIKPGSATPEPSEPSATESAPTEEKEEPKVDDPGTETDPDMPPLEGEEPEGEDDGEWETTSEKAESCSLSYSWTGALVTATRREERRHPIGPLSNTLITKHNLVYQTTTASASARMAKVTIDREQIFDKYYFDTVTAVKKKASEVAADLLTWDEVARLTPKNTARAKSGLSGSDVRQLTRAARRELTSMWQDLLSDSAEPIPTTVMAKNEVFVSSPTARKPARLIVYPDLPVRACEKRAMYDLFQKLPYAVMGKAYGFQYTPRQRVERLLEMWRHFKNPMGFSYDTKCFDSTVTPHDIDTERDIFLSANLPDEAKTVIKNLTSRLYRGSPMYNSRGDLVGKRECRASGVFPTSMGNTLTNFIKATAAAKAAGLSDPQFLICGDDLICITSSKGVEEDEQALRDFTGAMTKYSAIPGDLPKPYYDLEQITSCSSNVTVAQDRNGRPYYFLTRDPTTPLARASWETISHSPVNSWLGNIIAFAPTVWVRLVFLTHFFGLLLQQDAVDRNYEFEMYGSTYSVNPLDLPAIIYKLHGPEAFDLTNYSPYEVQRVAAALQKLGSPPLRAWKRRAKLVRSKLKVRGGRYAVVADYLFGFASAYRPKRPAPPGVNSIDVSGWFSIGDDSIGDIYRQLPVVAGKWIPLLLLLPLLAAILYFNK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias2307-2324Basic and acidic residues
Compositional bias2329-2347Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT880192
EMBL· GenBank· DDBJ
ALU58309.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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