A0A1D5BKM4 · A0A1D5BKM4_BRUMA

Function

function

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.

Features

Showing features for binding site.

131020406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site12[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site26[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site29[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site35[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site66-73ATP (UniProtKB | ChEBI)
Binding site240[4Fe-4S] cluster 2 (UniProtKB | ChEBI); ligand shared with heterodimeric partner
Binding site243[4Fe-4S] cluster 2 (UniProtKB | ChEBI); ligand shared with heterodimeric partner

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell projection
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent FeS chaperone activity
Molecular Functionmetal ion binding
Biological Processiron-sulfur cluster assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytosolic Fe-S cluster assembly factor NUBP1 homolog

Gene names

    • Name
      bma-nubp-1
    • Synonyms
      Bma-nubp-1
    • ORF names
      Bm14008
      , BM_Bm14008

Organism names

  • Taxonomic identifier
  • Strain
    • FR3
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Spiruromorpha > Filarioidea > Onchocercidae > Brugia

Accessions

  • Primary accession
    A0A1D5BKM4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain58-224AAA+ ATPase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    33,595
  • Last updated
    2016-11-30 v1
  • Checksum
    15C1E8082C4CE888
MNDVPENANEDCPGATSADAGKAFSCTGCPNQTLCASGEIRRPDSDLLAVTDRLKNVRHKILILSGKGGVGKSAVAANLARALAVNDKIQVGLLDIDICGPSQARMLGVEQESVHESGDGWCPIVVKDNLIVMSIAFLLQNRSEAVIWRGARKNALIKQFLKDVDWGTLDYLLIDTPPGTSDEHISIVQFLLQAGSVDGAIIVTTPQEISLLDVRKEINFCRRTKINILGIVENMSSFICPCCSNVSQLFPRTTGGAEMMCNELSVPLLALLPFDSHMAKCADSGEDYFEKYHNSALAKEFEKLAQLISK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A8PW87NUBP1_BRUMABm1_36105310

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN856980
EMBL· GenBank· DDBJ
CDP97271.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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