A0A1D5AKD0 · A0A1D5AKD0_SHEEP

  • Protein
    Chromogranin-A
  • Gene
    Chga
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Strongly inhibits glucose induced insulin release from the pancreas.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromaffin granule
Cellular Componentextracellular space
Cellular Componenttransport vesicle
Biological Processadenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation
Biological Processdefense response to bacterium
Biological Processnegative regulation of catecholamine secretion
Biological Processnegative regulation of insulin secretion

Names & Taxonomy

Protein names

  • Recommended name
    Chromogranin-A

Gene names

    • Name
      Chga

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis

Accessions

  • Primary accession
    A0A1D5AKD0

Subcellular Location

Keywords

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-57Basic and acidic residues
Region1-248Disordered
Compositional bias66-85Basic and acidic residues
Compositional bias186-214Basic and acidic residues
Compositional bias225-248Basic and acidic residues

Sequence similarities

Belongs to the chromogranin/secretogranin protein family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    248
  • Mass (Da)
    26,973
  • Last updated
    2016-11-30 v1
  • Checksum
    17C1819A78561422
KQRSSYEDGPSEGLEKPDDQAEPKEGMEEVSSKDAAEKRDDSKEVEKSDEDSDGDRPQASPELGPGFKVEEDKQAPGEEEEEAPSNAHPLASLPSPKHPGPQAKEDSEGPSQGPAGREKGLSAEQGRQTEREEEEEKGEEAEAGEKAVPEEESPTTAAFKPPPSLGNKETQRAAPGWPEALAVDGARKMGAEEAKSREGKGEWAHSRQEEEEMAGAQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMD

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias1-57Basic and acidic residues
Compositional bias66-85Basic and acidic residues
Compositional bias186-214Basic and acidic residues
Compositional bias225-248Basic and acidic residues
Non-terminal residue248

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT581624
EMBL· GenBank· DDBJ
AOG62079.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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