A0A1D5AKD0 · A0A1D5AKD0_SHEEP
- ProteinChromogranin-A
- GeneChga
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids248 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Strongly inhibits glucose induced insulin release from the pancreas.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | chromaffin granule | |
Cellular Component | extracellular space | |
Cellular Component | transport vesicle | |
Biological Process | adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation | |
Biological Process | defense response to bacterium | |
Biological Process | negative regulation of catecholamine secretion | |
Biological Process | negative regulation of insulin secretion |
Names & Taxonomy
Protein names
- Recommended nameChromogranin-A
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis
Accessions
- Primary accessionA0A1D5AKD0
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-57 | Basic and acidic residues | ||||
Sequence: KQRSSYEDGPSEGLEKPDDQAEPKEGMEEVSSKDAAEKRDDSKEVEKSDEDSDGDRP | ||||||
Region | 1-248 | Disordered | ||||
Sequence: KQRSSYEDGPSEGLEKPDDQAEPKEGMEEVSSKDAAEKRDDSKEVEKSDEDSDGDRPQASPELGPGFKVEEDKQAPGEEEEEAPSNAHPLASLPSPKHPGPQAKEDSEGPSQGPAGREKGLSAEQGRQTEREEEEEKGEEAEAGEKAVPEEESPTTAAFKPPPSLGNKETQRAAPGWPEALAVDGARKMGAEEAKSREGKGEWAHSRQEEEEMAGAQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMD | ||||||
Compositional bias | 66-85 | Basic and acidic residues | ||||
Sequence: GFKVEEDKQAPGEEEEEAPS | ||||||
Compositional bias | 186-214 | Basic and acidic residues | ||||
Sequence: ARKMGAEEAKSREGKGEWAHSRQEEEEMA | ||||||
Compositional bias | 225-248 | Basic and acidic residues | ||||
Sequence: SGEPEQEEQLSKEWEDAKRWSKMD |
Sequence similarities
Belongs to the chromogranin/secretogranin protein family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length248
- Mass (Da)26,973
- Last updated2016-11-30 v1
- Checksum17C1819A78561422
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: K | ||||||
Compositional bias | 1-57 | Basic and acidic residues | ||||
Sequence: KQRSSYEDGPSEGLEKPDDQAEPKEGMEEVSSKDAAEKRDDSKEVEKSDEDSDGDRP | ||||||
Compositional bias | 66-85 | Basic and acidic residues | ||||
Sequence: GFKVEEDKQAPGEEEEEAPS | ||||||
Compositional bias | 186-214 | Basic and acidic residues | ||||
Sequence: ARKMGAEEAKSREGKGEWAHSRQEEEEMA | ||||||
Compositional bias | 225-248 | Basic and acidic residues | ||||
Sequence: SGEPEQEEQLSKEWEDAKRWSKMD | ||||||
Non-terminal residue | 248 | |||||
Sequence: D |