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A0A1D3EDC4 · A0A1D3EDC4_NEIGO

  • Protein
    DNA topoisomerase 4 subunit B
  • Gene
    parE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

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Type
IDPosition(s)Description
Binding site7ATP (UniProtKB | ChEBI)
Binding site44ATP (UniProtKB | ChEBI)
Binding site71ATP (UniProtKB | ChEBI)
Binding site116-122ATP (UniProtKB | ChEBI)
Binding site351ATP (UniProtKB | ChEBI)
Site463Interaction with DNA
Site518Interaction with DNA
Site646Interaction with DNA

GO annotations

AspectTerm
Cellular Componentchromosome
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit B
  • EC number
  • Alternative names
    • Topoisomerase IV subunit B

Gene names

    • Name
      parE
    • ORF names
      E8M63_06490
      , WHOY_01032
      , WHOY_01471C

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • F89
    • WHO_Y
    • LRRBGS_0742
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    A0A1D3EDC4

Proteomes

Subcellular Location

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain429-546Toprim

Sequence similarities

Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    661
  • Mass (Da)
    72,113
  • Last updated
    2016-11-30 v1
  • MD5 Checksum
    6C0AF1E1B66D425F5D007AABDA7137AC
MAKNNQYSESSITVLKGLEPVKERPGMYTRTDSPTHICQEVIDNAADEALGGFATEIDVQIHEDGSLSVRDNGRGIPVGLHPEEGVPVVELVFTRLHAGGKFNKKDGGSAYAFSGGLHGVGVSVTNALSTRLEVSVKRDGKVHRIVFAGGDVVEPLAQVGKCAVKDSGTEVRVWPDGKYFESPNYSIPELERLLRAKAVLLPGVRVSLTRPVKGEDEAHTQTWHYPDGLKSYLTDLIADAQEAVPLFSCENYISDGHNGDFSIGEGAAFALTWLEEGSCANESYVNLIPTSLGGTHEAGLKQAVFNAVNNFINLHNLLPRGVKVQSDDVFGKTAFVLSARVLDPQFQGQTKDKLTNRDALKLVAAVSGDPLELWLNQNVDFGKKIAELAIRQAQARIRSVKKIEKKKGSGVAILPGKLTDCESEDIRENELFLVEGDSAGGSAKLARDKATQAILPLRGKVLNSFEVHPDQLFGNAEIHDISVAIGVDPHAINDHPDLSGLRYGKIAILSDADVDGSHIQVLLLTLFYRHFPKLVADGHIYVAQPPLFRVDVNAQGKSKPARKFYALDQNELDGILERLQKEGVKETAYSISRFKGLGEMNPDQLKDTTMHPDTRRLLQVQIPEGADDETRDIFVKLMGKGEAAARRAWMEREGDTAQLDI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FLKX01000011
EMBL· GenBank· DDBJ
SBM99888.1
EMBL· GenBank· DDBJ
Genomic DNA
LT592161
EMBL· GenBank· DDBJ
SBO69456.1
EMBL· GenBank· DDBJ
Genomic DNA
SUQX01000009
EMBL· GenBank· DDBJ
TJX05674.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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