A0A1D3EDC4 · A0A1D3EDC4_NEIGO
- ProteinDNA topoisomerase 4 subunit B
- GeneparE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids661 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Cofactor
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 7 | ATP (UniProtKB | ChEBI) | |||
Binding site | 44 | ATP (UniProtKB | ChEBI) | |||
Binding site | 71 | ATP (UniProtKB | ChEBI) | |||
Binding site | 116-122 | ATP (UniProtKB | ChEBI) | |||
Binding site | 351 | ATP (UniProtKB | ChEBI) | |||
Site | 463 | Interaction with DNA | |||
Site | 518 | Interaction with DNA | |||
Site | 646 | Interaction with DNA | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit B
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionA0A1D3EDC4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterotetramer composed of ParC and ParE.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 429-546 | Toprim | |||
Sequence similarities
Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length661
- Mass (Da)72,113
- Last updated2016-11-30 v1
- MD5 Checksum6C0AF1E1B66D425F5D007AABDA7137AC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FLKX01000011 EMBL· GenBank· DDBJ | SBM99888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LT592161 EMBL· GenBank· DDBJ | SBO69456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SUQX01000009 EMBL· GenBank· DDBJ | TJX05674.1 EMBL· GenBank· DDBJ | Genomic DNA |