A0A1D1W6R1 · A0A1D1W6R1_RAMVA

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • Name
      RvY_18622-1
    • Synonyms
      RvY_18622.1
    • ORF names
      RvY_18622

Organism names

Accessions

  • Primary accession
    A0A1D1W6R1

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane44-64Helical
Transmembrane85-107Helical
Transmembrane113-136Helical
Transmembrane148-169Helical
Transmembrane207-237Helical
Transmembrane269-294Helical
Transmembrane306-327Helical
Transmembrane334-356Helical
Transmembrane362-384Helical
Transmembrane391-414Helical
Transmembrane420-444Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-449Major facilitator superfamily (MFS) profile

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    505
  • Mass (Da)
    55,291
  • Last updated
    2016-11-30 v1
  • MD5 Checksum
    AAB7BFA8FDFB1E706384D26096FCD8B1
MPDALADQDRLVANMEQDEEDRAAPDDAASVTTPVGCCHPAGTGYRMVVLALVCLTSFGSYFCYDNPSALESEIKNDMDVSTGQYMLLYSLYSWPNVVVCFFGGFFIDRIIGVRWGAILFGGLLLIGHYIFALGAFVNRFWVMQMGRFIFGLGGENLAVAVNAYAVNWFKGSALNLVMGLSLSVSRVGSVLNMNTMKPLYNQLAKTYSGYTCLGLTLFIGGTTLILSQFCTFQLAWLDKRAKRILKPATVVAAGEKISFRDIKDFPWSLYLICAICVGYYTAIFPFISLGLVFYESKYGLSPQRAMLLNSLVYTISAVGSPILGFLIDRTGRNIIWTISAISITIVAHGILGFTFVNPFVAVSMMGVAYSMLASSLWPMVALVVKEHQLGTAYGIMQAVQNLGLAVFAIVAGTIVDKAGYLVLEVFFIGLLCVSLLSAAMLYLYDSKVNGLLNLSVLQQKARFDEEKRLAALREDNLVNGQTVVTEGKTTIEPVYPDNEAPRISF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BDGG01000020
EMBL· GenBank· DDBJ
GAV09016.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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