A0A1D1VGU6 · A0A1D1VGU6_RAMVA

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • Name
      RvY_11665-1
    • Synonyms
      RvY_11665.1
    • ORF names
      RvY_11665

Organism names

Accessions

  • Primary accession
    A0A1D1VGU6

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-24Helical
Transmembrane62-82Helical
Transmembrane89-109Helical
Transmembrane115-133Helical
Transmembrane153-173Helical
Transmembrane185-208Helical
Transmembrane242-260Helical
Transmembrane280-298Helical
Transmembrane307-325Helical
Transmembrane331-356Helical
Transmembrane368-388Helical
Transmembrane400-422Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-427Major facilitator superfamily (MFS) profile

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    51,869
  • Last updated
    2016-11-30 v1
  • MD5 Checksum
    87A728F17C05A3F5655EE27C328204CA
MADSKRWLFLLFTSIAIFGAEWVVDETGILASRLSGTSPDCFQKNGTDSTCLSMTDSQFNALYVVHFWAGSVISFLSGFLVTRYGVWNCSLATASALFSGMILFTVGPYCSSTTAAFAVMMVGRLLYGCGYWGNCVVSQQVKSHWFFGRELAVAFAVYNCSFRLGSIIAYPSVGAVVEKFGMQTTMWIVFAIGLVGPVTATIAGWIHLRYAEISMDSFVLEEVRHHTVKSTLGIVRHLTKHYWAVAAFLFFYYGGIMSVMSDFPKFLMEARNMAETQAGLISGIISDMALLSPLLGVFTDRYGWRDVQMVICSTLFLLGLLGLVSISGFNAILYCFIVGLSSAIMGACIWSGVVVVTTPGTVGVAMGLSSAFQTFGAGLFLLIGGFILDAGTDTKSKWLNFFVMGTCAVGVSLIAALAAWYLDSKTPHRPLRSRSSVKPSLVSAEDTMARRDSERDPFISNISSYSCEPEPTLPLIL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BDGG01000006
EMBL· GenBank· DDBJ
GAV00877.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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