A0A1C9ULF3 · A0A1C9ULF3_9GAST

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Heterobranchia > Euthyneura > Nudipleura > Nudibranchia > Cladobranchia > Fionoidea > Fionidae > Fiona

Accessions

  • Primary accession
    A0A1C9ULF3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane35-57Helical
Transmembrane78-102Helical
Transmembrane122-147Helical
Transmembrane159-186Helical
Transmembrane206-230Helical
Transmembrane242-266Helical
Transmembrane278-299Helical
Transmembrane311-328Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-329Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    329
  • Mass (Da)
    35,906
  • Last updated
    2016-11-30 v1
  • Checksum
    D973FBB34EB0736B
WCGLVGTGLSLLIRFELGTAGALLGDDHLYNVIVTAHAFVMIFFLVMPVMIGGFGNWMVPLLIGAPDMSFPRMNNMSFWLLPPSFLLLMSSTLMEGGAGTGWTVYPPLSGPMGHGGCSVDLAIFSLHLAGVSSLLGAVNFITTIFNMRSPEMTWDRLSLFVWSVMVTAFLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHILSNFSSKPAFGTLGMVYAMISIGVLGFIVWAHHMFTVGMDVDTRAYFTAATMVIAVPTGIKIFSWMMTLYGKRGPMSAPMYWVLGFIFLFTLGGLT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue329

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU757491
EMBL· GenBank· DDBJ
AOR81730.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757510
EMBL· GenBank· DDBJ
AOR81749.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757511
EMBL· GenBank· DDBJ
AOR81750.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757512
EMBL· GenBank· DDBJ
AOR81751.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757513
EMBL· GenBank· DDBJ
AOR81752.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757515
EMBL· GenBank· DDBJ
AOR81754.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757516
EMBL· GenBank· DDBJ
AOR81755.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757517
EMBL· GenBank· DDBJ
AOR81756.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757518
EMBL· GenBank· DDBJ
AOR81757.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757519
EMBL· GenBank· DDBJ
AOR81758.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757520
EMBL· GenBank· DDBJ
AOR81759.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757521
EMBL· GenBank· DDBJ
AOR81760.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757522
EMBL· GenBank· DDBJ
AOR81761.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757523
EMBL· GenBank· DDBJ
AOR81762.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757524
EMBL· GenBank· DDBJ
AOR81763.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757525
EMBL· GenBank· DDBJ
AOR81764.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757526
EMBL· GenBank· DDBJ
AOR81765.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757527
EMBL· GenBank· DDBJ
AOR81766.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757528
EMBL· GenBank· DDBJ
AOR81767.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757529
EMBL· GenBank· DDBJ
AOR81768.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757530
EMBL· GenBank· DDBJ
AOR81769.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757531
EMBL· GenBank· DDBJ
AOR81770.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757533
EMBL· GenBank· DDBJ
AOR81772.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757537
EMBL· GenBank· DDBJ
AOR81776.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757538
EMBL· GenBank· DDBJ
AOR81777.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757539
EMBL· GenBank· DDBJ
AOR81778.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757540
EMBL· GenBank· DDBJ
AOR81779.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757541
EMBL· GenBank· DDBJ
AOR81780.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757542
EMBL· GenBank· DDBJ
AOR81781.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757544
EMBL· GenBank· DDBJ
AOR81783.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757545
EMBL· GenBank· DDBJ
AOR81784.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757546
EMBL· GenBank· DDBJ
AOR81785.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757547
EMBL· GenBank· DDBJ
AOR81786.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757548
EMBL· GenBank· DDBJ
AOR81787.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757549
EMBL· GenBank· DDBJ
AOR81788.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757550
EMBL· GenBank· DDBJ
AOR81789.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757551
EMBL· GenBank· DDBJ
AOR81790.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757552
EMBL· GenBank· DDBJ
AOR81791.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757553
EMBL· GenBank· DDBJ
AOR81792.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757554
EMBL· GenBank· DDBJ
AOR81793.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757555
EMBL· GenBank· DDBJ
AOR81794.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757556
EMBL· GenBank· DDBJ
AOR81795.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757557
EMBL· GenBank· DDBJ
AOR81796.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757558
EMBL· GenBank· DDBJ
AOR81797.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757559
EMBL· GenBank· DDBJ
AOR81798.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757560
EMBL· GenBank· DDBJ
AOR81799.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757561
EMBL· GenBank· DDBJ
AOR81800.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757562
EMBL· GenBank· DDBJ
AOR81801.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757563
EMBL· GenBank· DDBJ
AOR81802.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757564
EMBL· GenBank· DDBJ
AOR81803.1
EMBL· GenBank· DDBJ
Genomic DNA
KU757568
EMBL· GenBank· DDBJ
AOR81807.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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