A0A1C9ULF3 · A0A1C9ULF3_9GAST
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids329 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Heterobranchia > Euthyneura > Nudipleura > Nudibranchia > Cladobranchia > Fionoidea > Fionidae > Fiona
Accessions
- Primary accessionA0A1C9ULF3
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 35-57 | Helical | ||||
Sequence: TAHAFVMIFFLVMPVMIGGFGNW | ||||||
Transmembrane | 78-102 | Helical | ||||
Sequence: FWLLPPSFLLLMSSTLMEGGAGTGW | ||||||
Transmembrane | 122-147 | Helical | ||||
Sequence: AIFSLHLAGVSSLLGAVNFITTIFNM | ||||||
Transmembrane | 159-186 | Helical | ||||
Sequence: LFVWSVMVTAFLLLLSLPVLAGAITMLL | ||||||
Transmembrane | 206-230 | Helical | ||||
Sequence: LYQHLFWFFGHPEVYILILPGFGII | ||||||
Transmembrane | 242-266 | Helical | ||||
Sequence: AFGTLGMVYAMISIGVLGFIVWAHH | ||||||
Transmembrane | 278-299 | Helical | ||||
Sequence: AYFTAATMVIAVPTGIKIFSWM | ||||||
Transmembrane | 311-328 | Helical | ||||
Sequence: APMYWVLGFIFLFTLGGL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-329 | Cytochrome oxidase subunit I profile | ||||
Sequence: WCGLVGTGLSLLIRFELGTAGALLGDDHLYNVIVTAHAFVMIFFLVMPVMIGGFGNWMVPLLIGAPDMSFPRMNNMSFWLLPPSFLLLMSSTLMEGGAGTGWTVYPPLSGPMGHGGCSVDLAIFSLHLAGVSSLLGAVNFITTIFNMRSPEMTWDRLSLFVWSVMVTAFLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHILSNFSSKPAFGTLGMVYAMISIGVLGFIVWAHHMFTVGMDVDTRAYFTAATMVIAVPTGIKIFSWMMTLYGKRGPMSAPMYWVLGFIFLFTLGGLT |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length329
- Mass (Da)35,906
- Last updated2016-11-30 v1
- ChecksumD973FBB34EB0736B
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: W | ||||||
Non-terminal residue | 329 | |||||
Sequence: T |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KU757491 EMBL· GenBank· DDBJ | AOR81730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757510 EMBL· GenBank· DDBJ | AOR81749.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757511 EMBL· GenBank· DDBJ | AOR81750.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757512 EMBL· GenBank· DDBJ | AOR81751.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757513 EMBL· GenBank· DDBJ | AOR81752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757515 EMBL· GenBank· DDBJ | AOR81754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757516 EMBL· GenBank· DDBJ | AOR81755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757517 EMBL· GenBank· DDBJ | AOR81756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757518 EMBL· GenBank· DDBJ | AOR81757.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757519 EMBL· GenBank· DDBJ | AOR81758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757520 EMBL· GenBank· DDBJ | AOR81759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757521 EMBL· GenBank· DDBJ | AOR81760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757522 EMBL· GenBank· DDBJ | AOR81761.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757523 EMBL· GenBank· DDBJ | AOR81762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757524 EMBL· GenBank· DDBJ | AOR81763.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757525 EMBL· GenBank· DDBJ | AOR81764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757526 EMBL· GenBank· DDBJ | AOR81765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757527 EMBL· GenBank· DDBJ | AOR81766.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757528 EMBL· GenBank· DDBJ | AOR81767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757529 EMBL· GenBank· DDBJ | AOR81768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757530 EMBL· GenBank· DDBJ | AOR81769.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757531 EMBL· GenBank· DDBJ | AOR81770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757533 EMBL· GenBank· DDBJ | AOR81772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757537 EMBL· GenBank· DDBJ | AOR81776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757538 EMBL· GenBank· DDBJ | AOR81777.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757539 EMBL· GenBank· DDBJ | AOR81778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757540 EMBL· GenBank· DDBJ | AOR81779.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757541 EMBL· GenBank· DDBJ | AOR81780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757542 EMBL· GenBank· DDBJ | AOR81781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757544 EMBL· GenBank· DDBJ | AOR81783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757545 EMBL· GenBank· DDBJ | AOR81784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757546 EMBL· GenBank· DDBJ | AOR81785.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757547 EMBL· GenBank· DDBJ | AOR81786.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757548 EMBL· GenBank· DDBJ | AOR81787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757549 EMBL· GenBank· DDBJ | AOR81788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757550 EMBL· GenBank· DDBJ | AOR81789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757551 EMBL· GenBank· DDBJ | AOR81790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757552 EMBL· GenBank· DDBJ | AOR81791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757553 EMBL· GenBank· DDBJ | AOR81792.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757554 EMBL· GenBank· DDBJ | AOR81793.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757555 EMBL· GenBank· DDBJ | AOR81794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757556 EMBL· GenBank· DDBJ | AOR81795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757557 EMBL· GenBank· DDBJ | AOR81796.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757558 EMBL· GenBank· DDBJ | AOR81797.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757559 EMBL· GenBank· DDBJ | AOR81798.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757560 EMBL· GenBank· DDBJ | AOR81799.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757561 EMBL· GenBank· DDBJ | AOR81800.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757562 EMBL· GenBank· DDBJ | AOR81801.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757563 EMBL· GenBank· DDBJ | AOR81802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757564 EMBL· GenBank· DDBJ | AOR81803.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU757568 EMBL· GenBank· DDBJ | AOR81807.1 EMBL· GenBank· DDBJ | Genomic DNA |