A0A1C9J735 · A0A1C9J735_HUMAN

  • Protein
    Histone-lysine N-methyltransferase, H3 lysine-79 specific
  • Gene
    DOT1L
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Histone methyltransferase. Methylates 'Lys-79' of histone H3.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site136-139S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site159-168S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site186S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site222-223S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone H3K79 trimethyltransferase activity
Biological ProcessDNA damage checkpoint signaling
Biological ProcessDNA repair
Biological Processheterochromatin formation
Biological Processmethylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene names

    • Name
      DOT1L

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1C9J735

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

PTM databases

Family & Domains

Features

Showing features for domain, compositional bias, region, coiled coil.

TypeIDPosition(s)Description
Domain16-330DOT1
Compositional bias334-349Basic and acidic residues
Region334-480Disordered
Compositional bias390-415Basic residues
Compositional bias416-431Basic and acidic residues
Compositional bias433-469Polar residues
Coiled coil529-636
Region785-853Disordered
Compositional bias809-823Polar residues
Region950-1269Disordered
Compositional bias962-991Polar residues
Compositional bias998-1012Polar residues
Compositional bias1051-1068Polar residues
Compositional bias1116-1156Polar residues
Region1284-1319Disordered
Region1331-1406Disordered

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,537
  • Mass (Da)
    164,910
  • Last updated
    2016-11-30 v1
  • Checksum
    5520736A0DDA5D56
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRXKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias334-349Basic and acidic residues
Compositional bias390-415Basic residues
Compositional bias416-431Basic and acidic residues
Compositional bias433-469Polar residues
Compositional bias809-823Polar residues
Compositional bias962-991Polar residues
Compositional bias998-1012Polar residues
Compositional bias1051-1068Polar residues
Compositional bias1116-1156Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX792914
EMBL· GenBank· DDBJ
AOP12924.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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