A0A1C8ZQC7 · A0A1C8ZQC7_9CREN

  • Protein
    Type 2 DNA topoisomerase 6 subunit B
  • Gene
    top6B
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

153150100150200250300350400450500
TypeIDPosition(s)Description
Binding site43ATP (UniProtKB | ChEBI)
Binding site77ATP (UniProtKB | ChEBI)
Binding site98-99ATP (UniProtKB | ChEBI)
Binding site107-114ATP (UniProtKB | ChEBI)
Binding site428ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological ProcessDNA topological change
Biological ProcessDNA unwinding involved in DNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Type 2 DNA topoisomerase 6 subunit B
  • EC number
  • Alternative names
    • Type II DNA topoisomerase VI subunit B
      (TopoVI-B
      )

Gene names

    • Name
      top6B
    • ORF names
      BFU36_01580

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • A20
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfolobus

Accessions

  • Primary accession
    A0A1C8ZQC7

Proteomes

Interaction

Subunit

Homodimer. Heterotetramer of two Top6A and two Top6B chains.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain28-149Histidine kinase/HSP90-like ATPase
Coiled coil431-466

Sequence similarities

Belongs to the TOP6B family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    531
  • Mass (Da)
    60,966
  • Last updated
    2016-11-30 v1
  • Checksum
    FE9BF11F4D170A04
MSASKEKFTSLSPAEFFKRNPELAGFPNTARALYQTVRELVENALDATDVHGILPNIKISIDLIDANTQIYKVNVADNGIGIPPHEVPNAFGKVLYSSKYVNRQTRGMYGLGVKAAVLYSQMHQDRPIEIETSPINSKRIYVFKLKIDINKNEPIIVERGSVINDKDFHGTSVAIYIPGDWTKAKSRVYEYIRRTYLITPYAEFIFKDPEGNVNYFPRLTNKIPKPPQEVKPHPYGVDREEIKIIANNLKKDYTIKEFLINEFQSVGEITADKILELAGLRGNKKVKSLTEEEITRLVEAFKKFEDLRPPSADSLSVIGSDLIELGLKKIYNPEFAVAVTRRPKSYQGHPFVVEVGIAYGGNIQASEEPIVLRYANKIPLIYDEKSDVIWKVVEEMDWKRYGIEGEQYQMVVMVHLCSTKIPYKSAGKESIAEVEDIEKEIRNALMEAARKMKQFLTEKRKEEEEKKKLLTYLKYIPEVSRSFSIFMSDGNREAALKIQNELENELFKLISRKLNLINIEEYRKLYRVDSE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017006
EMBL· GenBank· DDBJ
AOL15638.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp