A0A1C5V6V6 · A0A1C5V6V6_9CLOT

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA_2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1855100200300400500600700800
TypeIDPosition(s)Description
Binding site85ATP (UniProtKB | ChEBI)
Binding site103-107ATP (UniProtKB | ChEBI)
Binding site512ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA_2
    • Synonyms
      secA
    • ORF names
      SAMEA3545291_03361

Organism names

  • Taxonomic identifier
  • Strain
    • 2789STDY5608883
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium > environmental samples

Accessions

  • Primary accession
    A0A1C5V6V6

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain1-590SecA family profile
Domain87-225Helicase ATP-binding
Domain422-606Helicase C-terminal
Region808-845Disordered

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    855
  • Mass (Da)
    97,444
  • Last updated
    2016-11-02 v1
  • MD5 Checksum
    BED5F28464D8EAC66AA7F0347E6ADF2C
MSVIEKIFGTHSSRELKRIEPLVDKIEALRPTMQALSDEELRGKTEEYKKRLTEGETLDDLLPEAYATVREAAKRVLNMEHYRVQLIGGIILHQGRIAEMRTGEGKTLVSTLPAYLNALEGKGVHVVTVNDYLAKRDAEWMGQVHEFLGLKVGVVLNSMTSEERQEAYKCDITYVTNNELGFDYLRDNMVIYKEQLVLRGLHYAIIDEVDSVLIDEARTPLIISGQSGKSTALYEMCDLLARQMKRGDDVQELTKMDAIMGVVQEETGDFVVNEKDKIINLTAAGMEKVERFFHIDNFADPENLEIQHNIILALRAHNLMFRDKDYVVKDDQVLIVDEFTGRIMPGRRYSDGLHQAIEAKEHVKVKRESKTLASITFQNFFNLFDKKCGMTGTALTEETEFREIYGMDVVVIPTNRPVIRKDLQDAVYKTKREKLNAIVNAVEEAHATGQPVLVGTITIEASEELSRMLTKRGIQHKVLNAKFHELEAEIVADAGVHGAVTIATNMAGRGTDIKLDDEARAAGGLKIIGTERHESRRIDNQLRGRSGRQGDPGESKFYISLEDDLMRLFGSERLISMFNTLGIPEGQEIEHKALTNAIESAQKKIESNNYGIRKNLLEYDRVMSEQREIIYEERLRVLNGESMRDVIYKMITDITENCVDICINDDADISDWDFNELNTLLIPTIPLQPLTPERVKKPKKNSLKQQLKEEAVKLYEAKEAEFPEPEAIRELERVVLLKVIDRKWMDHIDDMEQLRQGVGLQAYGQRDPLVEYKMSGYEMFDEMTQNIREETVRLLFHIKIEQKVEREQQAKITGTNKDDSLPKGPVKRENAKVYPNDPCPCGSGKKYKNCCGRKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FMDR01000035
EMBL· GenBank· DDBJ
SCI06263.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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