A0A1C5R8I4 · A0A1C5R8I4_9CLOT

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site70substrate
Binding site199-201substrate
Binding site208Mn2+ (UniProtKB | ChEBI)
Binding site228Mn2+ (UniProtKB | ChEBI)
Binding site250substrate
Binding site251-256GTP (UniProtKB | ChEBI)
Active site252
Binding site279Mn2+ (UniProtKB | ChEBI)
Binding site372-374substrate
Binding site374GTP (UniProtKB | ChEBI)
Binding site405GTP (UniProtKB | ChEBI)
Binding site499-502GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      SAMEA3545249_01323

Organism names

  • Taxonomic identifier
  • Strain
    • 2789STDY5608841
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium > environmental samples

Accessions

  • Primary accession
    A0A1C5R8I4

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-219Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain224-588Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    591
  • Mass (Da)
    65,614
  • Last updated
    2016-11-02 v1
  • MD5 Checksum
    24DC6DC89BA5EDC7F9583BA25896C2AD
MLTNNKNVLNWVEEMVALCKPDQVVWIDGSEEQLKALTDEAVSTGEMERLNEEKLPGCLLHRTNPNDVARVEARTFICSRKEEDAGPTNNWCDPKEMYAKLTPMYDGVMKGRTMYVIPYSMGPIGSPLAKVGVELTDSIYVVLNMDIMTRVGKAAFENLGDVSNDFVRGLHSKADVDPENRYIVHFPEDNTIWSINSGYGGNVLLGKKCFALRIASYQGKNEGWMAEHMLILGIEAPNGETTYISAAFPSACGKTNLAMLIPPEVYAKQGYKVWTVGDDIAWLKPGADGRLYAINPENGFFGVAPGTNMKSNPNALKTTMKDTIFTNVAHNLDDNTVWWEGLDKNPPEHAVEWTGKPWNGKTDTDVKGAHPNSRFTAPARNCPCISPEFDNPQGVPISAMVFGGRRAKTAPLVYQSFDWKHGVFVGSTMASETTAAATGAVGVVRRDPMAMLPFCGYHMGDYFAHWLEMGEKLGDKAPKIFNVNWFRTDDEGHFIWPGFGDNMRVLMWIVARCKGEADAVETPIGYEPKPEDINLEGLDIDLDTLKGLLNVDIDLWKEEAAGIHEFYAKFGDKLPEELKHQLAALEERLGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FMEM01000003
EMBL· GenBank· DDBJ
SCH57715.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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