A0A1C5PJS3 · A0A1C5PJS3_9CLOT

Function

function

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site35Zn2+ (UniProtKB | ChEBI)
Binding site38Zn2+ (UniProtKB | ChEBI)
Binding site54Zn2+ (UniProtKB | ChEBI)
Binding site57Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentacetyl-CoA carboxylase complex
Molecular Functionacetyl-CoA carboxylase activity
Molecular FunctionATP binding
Molecular Functioncarboxyl- or carbamoyltransferase activity
Molecular Functionzinc ion binding
Biological Processfatty acid biosynthetic process
Biological Processmalonyl-CoA biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
  • EC number
  • Short names
    ACCase subunit alpha
    ; Acetyl-CoA carboxylase carboxyltransferase subunit alpha
  • Recommended name
    Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
  • Short names
    ACCase subunit beta
    ; Acetyl-CoA carboxylase carboxyltransferase subunit beta

Gene names

    • Name
      accD
    • Synonyms
      accA
    • ORF names
      SAMEA2393091_01384

Organism names

  • Taxonomic identifier
  • Strain
    • 2789STDY5608795
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium > environmental samples

Accessions

  • Primary accession
    A0A1C5PJS3

Subcellular Location

Keywords

Interaction

Subunit

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.

Family & Domains

Features

Showing features for domain, zinc finger.

TypeIDPosition(s)Description
Domain31-297CoA carboxyltransferase N-terminal
Zinc finger35-57C4-type
Domain296-552CoA carboxyltransferase C-terminal

Sequence similarities

Belongs to the AccA family.
Belongs to the AccD/PCCB family.
In the C-terminal section; belongs to the AccA family.
In the N-terminal section; belongs to the AccD/PCCB family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    572
  • Mass (Da)
    63,602
  • Last updated
    2016-11-02 v1
  • Checksum
    9882556F94338FC4
MKLDNMFKKNRGTSMKRIAHRQAGPEVPEGLMRKCNQCGKAIIAEDAEQGYYICPKCGGYFHVPAYRRLDMILDEGSFQEWNETMPEQNPMEYRGYPEKLAAMKARTGLDEAVVTGKGSIHGTETVIGVCDGRFLMASMGENVGEKIACAVERATEEQLPVILFCCSGGARMQEGITSLMQMAKTSAALKRHSDAGLLYISVLTDPTTGGVTASFAMLGDIILAEPGALIGFAGPRVIEQTIRQKLPKGFQRAEFLLEHGFLDAIVERSRMQKVLGNLLQMHGKAAWEEQSQEAAELKSSEDRTERSHVSVQKKEAWDRVLLSRKKDRPVGSDYIQALFTNFQEFHGDRLYGDDSAIIGGIASFGDRAVTVIAQEKGRSTRENIQRNFAMPKPDGYRKALRLMKQAEKFHRPVICFVDTPGAFCGIEAEERGQGEAIARNIYEMSALKVPILTVIIGEGGSGGALALATSDEVWMLENAIYSILSPEGFASILWKDSTKAKEAAKVMKLTSDCLKEQGIVDNVISEPEGFSRENLYLVTGPMEEEIKRFLNQYGNMLEEELTEHRYQRFRKM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FMDQ01000005
EMBL· GenBank· DDBJ
SCH37196.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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