A0A1C5KKW5 · A0A1C5KKW5_9CLOT

  • Protein
    ATP-dependent 6-phosphofructokinase
  • Gene
    pfkA_1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site11ATP (UniProtKB | ChEBI)
Binding site74-75ATP (UniProtKB | ChEBI)
Binding site111-114ATP (UniProtKB | ChEBI)
Binding site112Mg2+ (UniProtKB | ChEBI); catalytic
Site113Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site134-136substrate; ligand shared between dimeric partners; in other chain
Active site136Proton acceptor
Binding site171substrate; ligand shared between dimeric partners
Binding site178-180substrate; ligand shared between dimeric partners; in other chain
Binding site231substrate; ligand shared between dimeric partners; in other chain
Binding site275substrate; ligand shared between dimeric partners
Binding site281-284substrate; ligand shared between dimeric partners; in other chain

GO annotations

AspectTerm
Cellular Component6-phosphofructokinase complex
Molecular Function6-phosphofructokinase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionfructose-6-phosphate binding
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmonosaccharide binding
Biological Processcanonical glycolysis
Biological Processfructose 1,6-bisphosphate metabolic process
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      pfkA_1
    • Synonyms
      pfkA
    • ORF names
      SAMEA3545239_01838

Organism names

  • Taxonomic identifier
  • Strain
    • 2789STDY5608831
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium > environmental samples

Accessions

  • Primary accession
    A0A1C5KKW5

Subcellular Location

Keywords

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-307Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    38,748
  • Last updated
    2016-11-02 v1
  • Checksum
    C7CEBB1F7F32F3FF
MKRIGLLTSGGDCQALNATMRGVVKGLSNSLDELEVYGFMNGYKGLIYGDYRMLTAKDFSGILTKGGTILGSSRQPFKLMRVPDENGLDKVEAMKQNYYKLRLDCLVILGGNGTQKTANLLREEGLNIIHLPKTIDNDIYGTDMTFGFQSAVDIATDAIDCIHTTAASHNRVFIVEVMGHKVGWLTLYAGIAGGADIVLIPEIPYDIDKVVEAIDKRTKAGKGFTILAVAEGAISKEDAALPKKEYKEKLANRKHPSVSYELAEQILEKTGVEVRITVPGHTQRGGSPCPYDRVLSTRLGAAAAQLILKEDYGYMVGMVNGKCKKVPLGEVAGKLKMVSPDDQIIRQAKLTGISFGD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FMDP01000009
EMBL· GenBank· DDBJ
SCG88703.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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