A0A1C3NSL9 · AJM1_CAEEL
- ProteinApical junction molecule
- Geneajm-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1644 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Controls adherens junction integrity (PubMed:11715019).
Required for the correct rate and completion of elongation of the embryos (PubMed:11715019).
Required for the correct rate and completion of elongation of the embryos (PubMed:11715019).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 1445 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1448 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1464 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1467 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1472 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1476 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1484 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 1488 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | adherens junction | |
Cellular Component | apical junction complex | |
Cellular Component | apical plasma membrane | |
Cellular Component | apicolateral plasma membrane | |
Cellular Component | cell-cell junction | |
Cellular Component | ciliary basal body | |
Cellular Component | dendrite terminus | |
Cellular Component | plasma membrane | |
Molecular Function | cytoskeletal protein binding | |
Molecular Function | metal ion binding | |
Biological Process | cell-cell junction organization | |
Biological Process | embryo development ending in birth or egg hatching |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameApical junction molecule
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionA0A1C3NSL9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mutant embryos enclose normally and initiate elongation without obvious morphological abnormalities, yet at a slower rate than the wild type. Elongation is consistently arrested at the 2-3-fold stage, accompanied by the formation of a large vacuole in the posterior region.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000442928 | 1-1644 | Apical junction molecule | |||
Sequence: MSTTTPEKPEEIIDATGTSDTAEKIEVVISKEEPAEQKNEVEEPDYAQVPAESEDDAAQELAPTDSAIQVVHVLEAPQKAELVTIPLAHSEAEDHKLADADRDQEEELVFNEERRKTVTMDDNASLRSASITFDANRDEQDLLNESFASNPTDETVLMQKTKDEMDATSERPRSPLDLPPPPASVVLHPSAPPPPPPPLSSTEVVGNTTTTTTTHYAPKTWNDPSITTAPKIPVSLLSGAQPLPSVLTQRTTTSSYSAPNYSASSMSGVPSDVAPPPPLPIPNQSSSSAASYQHHHASSISKSISSSREDLLSEHATSRSTVREIPVHRAPSTAPSHSSVFEYHMMPTTTSTYHHVETPSDEYYRREVMTRTIITRSTEALSQTPLGRPASPLDRYLPYPTTTTTTSGDGRTREEKTVDYKVTYHRDIEEQERRIREDQARRQQEEQDRRDREDNARRILAQREHQEMERLREQQNLSERALAERERADKERLQQERLLRQQREKKRREEWDRLESIRLAEEEAELARRRALEKERIDREKAEEERKTMERLERERARLERERLEEERRQKEKAETERIERERREHERIEIERIERIKRERIERERREREEKKAEEDRLLRERLELERIERERRELEARERQELELQRREAEDRERQRLEDEAREMRRREEERREAELVADVHRQAEERERLRKRQEREEAERLERIRLEQQKIDMERIDAERRERERKEEERREFELIEAARRKKEARDRDRLDEMERERVREEEERREKERREQERRIAAEKERKRRQEEEEEIARLNELQRAAAARQAQRNAELDRQRQRDELDRKAQELSEREMREKERRDRERANEEAQLADLLERERHNQLIRENERREAVERANNRRLEDRRSRDKLDHIVRERSEKEQFELEKRRLLAEKEAMNRKKNHLLSSETLAKLTQPMYYTTREPEVTTKVERQVIERIDRNVWVEDVPYAPSQSAMGYLDNDENNRDRLYNPNDLNRNGSSRSRYQRAKNEKARRDFYHSSQDSADPVTERFRKSTDDLTTRSRPEYRGPLLQKFHDSEFRTTALNETDGLPYRRMGPSPYEQPFAKLLEETERRYAHYNSRASNPSIYQSSRYYYPERHGQPQHTDNTRAESVVAYERESRRESPADQAHIRSRSADYLMDRRIREETEVPENQLQKTRVEPHDQSPRESRISEYEMRFRKSTEKLTVPDWYRENRPQGQTAQTSTYRYGNGVEPMSTTTTTTTVINGTSSHQQAPPPVPPQPIGNIGLPRGMFDRYKDDIEELRRSRSSLHQTGQQETSNRQGSTLSVGGIVDQGHALPGYTVSEVPNAWNLHTSRTSRVVEVADTFVGTSSHEYGNFTNRYGGRVTIEEVLDSIFQKVTPTNQRLNFDRSYPQADELFQGNVDGPGIYTNNYSVMRQVLKSPERAEHILQNEELFVRCTECHRTRELSAARLFFVSCKHCYTYYCSRECRHNNWPNHSGRCSFARINTLCKDVIMKVREDEQAQAFMSKVARDGFSVSGRGSVNIRLSSPQLAQAYVSNGWRALSAYPNDQLLYYYTVKALIAERKEPSLIALCNRYEPREKFILSVSIIADIEHCPETPPPETRELSAVQFSSPRSRYEAIQNQNAPYFSEFAHNV |
Proteomic databases
Expression
Tissue specificity
Expressed by epithelial cells (PubMed:11715019).
Expressed in sensory neuron dendritic tips (PubMed:27623382).
Expressed in sensory neuron dendritic tips (PubMed:27623382).
Developmental stage
Expression occurs in the embryonic hypodermis, pharynx and intestine, as well as in postembryonic epithelia, including the vulva, uterus, spermathecae, pharynx, intestine, hindgut, hypodermis and male tail.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MSTTTPEKPEEIIDATGTSD | ||||||
Compositional bias | 30-45 | Basic and acidic residues | ||||
Sequence: SKEEPAEQKNEVEEPD | ||||||
Region | 30-60 | Disordered | ||||
Sequence: SKEEPAEQKNEVEEPDYAQVPAESEDDAAQE | ||||||
Compositional bias | 142-156 | Polar residues | ||||
Sequence: LLNESFASNPTDETV | ||||||
Region | 142-339 | Disordered | ||||
Sequence: LLNESFASNPTDETVLMQKTKDEMDATSERPRSPLDLPPPPASVVLHPSAPPPPPPPLSSTEVVGNTTTTTTTHYAPKTWNDPSITTAPKIPVSLLSGAQPLPSVLTQRTTTSSYSAPNYSASSMSGVPSDVAPPPPLPIPNQSSSSAASYQHHHASSISKSISSSREDLLSEHATSRSTVREIPVHRAPSTAPSHSS | ||||||
Compositional bias | 157-171 | Basic and acidic residues | ||||
Sequence: LMQKTKDEMDATSER | ||||||
Compositional bias | 174-201 | Pro residues | ||||
Sequence: SPLDLPPPPASVVLHPSAPPPPPPPLSS | ||||||
Compositional bias | 202-234 | Polar residues | ||||
Sequence: TEVVGNTTTTTTTHYAPKTWNDPSITTAPKIPV | ||||||
Compositional bias | 241-269 | Polar residues | ||||
Sequence: QPLPSVLTQRTTTSSYSAPNYSASSMSGV | ||||||
Compositional bias | 284-307 | Polar residues | ||||
Sequence: QSSSSAASYQHHHASSISKSISSS | ||||||
Region | 381-455 | Disordered | ||||
Sequence: LSQTPLGRPASPLDRYLPYPTTTTTTSGDGRTREEKTVDYKVTYHRDIEEQERRIREDQARRQQEEQDRRDREDN | ||||||
Compositional bias | 409-455 | Basic and acidic residues | ||||
Sequence: DGRTREEKTVDYKVTYHRDIEEQERRIREDQARRQQEEQDRRDREDN | ||||||
Coiled coil | 428-924 | |||||
Sequence: IEEQERRIREDQARRQQEEQDRRDREDNARRILAQREHQEMERLREQQNLSERALAERERADKERLQQERLLRQQREKKRREEWDRLESIRLAEEEAELARRRALEKERIDREKAEEERKTMERLERERARLERERLEEERRQKEKAETERIERERREHERIEIERIERIKRERIERERREREEKKAEEDRLLRERLELERIERERRELEARERQELELQRREAEDRERQRLEDEAREMRRREEERREAELVADVHRQAEERERLRKRQEREEAERLERIRLEQQKIDMERIDAERRERERKEEERREFELIEAARRKKEARDRDRLDEMERERVREEEERREKERREQERRIAAEKERKRRQEEEEEIARLNELQRAAAARQAQRNAELDRQRQRDELDRKAQELSEREMREKERRDRERANEEAQLADLLERERHNQLIRENERREAVERANNRRLEDRRSRDKLDHIVRERSEKEQFELEKRRLLAEKEAMNRK | ||||||
Region | 561-583 | Disordered | ||||
Sequence: RERLEEERRQKEKAETERIERER | ||||||
Region | 647-678 | Disordered | ||||
Sequence: QRREAEDRERQRLEDEAREMRRREEERREAEL | ||||||
Compositional bias | 744-800 | Basic and acidic residues | ||||
Sequence: RKKEARDRDRLDEMERERVREEEERREKERREQERRIAAEKERKRRQEEEEEIARLN | ||||||
Region | 744-851 | Disordered | ||||
Sequence: RKKEARDRDRLDEMERERVREEEERREKERREQERRIAAEKERKRRQEEEEEIARLNELQRAAAARQAQRNAELDRQRQRDELDRKAQELSEREMREKERRDRERANE | ||||||
Compositional bias | 814-851 | Basic and acidic residues | ||||
Sequence: NAELDRQRQRDELDRKAQELSEREMREKERRDRERANE | ||||||
Region | 977-1052 | Disordered | ||||
Sequence: QSAMGYLDNDENNRDRLYNPNDLNRNGSSRSRYQRAKNEKARRDFYHSSQDSADPVTERFRKSTDDLTTRSRPEYR | ||||||
Compositional bias | 1008-1052 | Basic and acidic residues | ||||
Sequence: RYQRAKNEKARRDFYHSSQDSADPVTERFRKSTDDLTTRSRPEYR | ||||||
Region | 1122-1198 | Disordered | ||||
Sequence: ERHGQPQHTDNTRAESVVAYERESRRESPADQAHIRSRSADYLMDRRIREETEVPENQLQKTRVEPHDQSPRESRIS | ||||||
Compositional bias | 1136-1198 | Basic and acidic residues | ||||
Sequence: ESVVAYERESRRESPADQAHIRSRSADYLMDRRIREETEVPENQLQKTRVEPHDQSPRESRIS | ||||||
Region | 1292-1315 | Disordered | ||||
Sequence: SRSSLHQTGQQETSNRQGSTLSVG | ||||||
Compositional bias | 1295-1315 | Polar residues | ||||
Sequence: SLHQTGQQETSNRQGSTLSVG | ||||||
Zinc finger | 1445-1488 | MYND-type | ||||
Sequence: CTECHRTRELSAARLFFVSCKHCYTYYCSRECRHNNWPNHSGRC |
Domain
The coiled-coil domain is sufficient to localize to apical junctions.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 11 isoforms produced by Alternative splicing.
A0A1C3NSL9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,644
- Mass (Da)193,402
- Last updated2016-11-02 v1
- ChecksumF57A629DDA31B700
A0A1C3NSL9-2
- Name2
- Differences from canonical
- 1-467: Missing
A0A1C3NSL9-3
- Name3
- Differences from canonical
- 1-368: Missing
A0A1C3NSL9-4
- Name4
- Differences from canonical
- 1-119: Missing
A0A1C3NSL9-5
- Name5
- Differences from canonical
- 1-96: MSTTTPEKPEEIIDATGTSDTAEKIEVVISKEEPAEQKNEVEEPDYAQVPAESEDDAAQELAPTDSAIQVVHVLEAPQKAELVTIPLAHSEAEDHK → MIPFDPTTSEIHTQKMSQFIV
A0A1C3NSL9-6
- Name6
- Differences from canonical
- 1-1: M → MDIENLQSSNNRSQKSRPPDGFNAILQTAFSAILAFVLSLRIIVFATARKRLTTTAANPDIQVEEASSSSSDTSSDTEIVEEGVFIQRQGEPTMSEKKPAQGMPSVMSLLQTDEILSSCSDDEPTTSGLIPLPSLIQSNMSVLPNFLHTINEEESDEIRSLTGSSLASPRTVVDRRLSNISLLSPTPDEDFGLEQQEQQPENSEEVRGRESRTSLEEERIVVGEPRTTRQIEITQSASEDDRLDLLKELAKIGKSNTSTSQM
A0A1C3NSL9-7
- Name7
- Differences from canonical
- 1-265: Missing
A0A1C3NSL9-8
- Name8
- Differences from canonical
- 1-1: M → MDIENLQSSNNRSQKSRPPDGFNAILQTAFSAILAFVLSLRIIVFATARKRLTTTAANPDIQVEEASSSSSDTSSDTEIVEEGVFIQRQGEPTMSEKKPAQGMPSVMSLLQTDEILSSCSDDEPTTSGLIPLPSLIQSNMSVLPNFLHTINEEESDEIRSLTGSSLASPRTVVDRRLSNISLLSPTPDEDFGLEQQEQQPENSEEVRGRESRTSLEEERIVVGEPRTTRQIEITQSASEDDRLDLLKELAKIGKSNTSTSQM
- 1088-1128: Missing
A0A1C3NSL9-9
- Name9
- Differences from canonical
- 1-157: Missing
A0A1C3NSL9-10
- Name10
- Differences from canonical
- 1-164: Missing
A0A1C3NSL9-11
- Name11
- Differences from canonical
- 1-344: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_059293 | 1 | in isoform 6 and isoform 8 | |||
Sequence: M → MDIENLQSSNNRSQKSRPPDGFNAILQTAFSAILAFVLSLRIIVFATARKRLTTTAANPDIQVEEASSSSSDTSSDTEIVEEGVFIQRQGEPTMSEKKPAQGMPSVMSLLQTDEILSSCSDDEPTTSGLIPLPSLIQSNMSVLPNFLHTINEEESDEIRSLTGSSLASPRTVVDRRLSNISLLSPTPDEDFGLEQQEQQPENSEEVRGRESRTSLEEERIVVGEPRTTRQIEITQSASEDDRLDLLKELAKIGKSNTSTSQM | ||||||
Alternative sequence | VSP_059292 | 1-96 | in isoform 5 | |||
Sequence: MSTTTPEKPEEIIDATGTSDTAEKIEVVISKEEPAEQKNEVEEPDYAQVPAESEDDAAQELAPTDSAIQVVHVLEAPQKAELVTIPLAHSEAEDHK → MIPFDPTTSEIHTQKMSQFIV | ||||||
Alternative sequence | VSP_059291 | 1-119 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_059290 | 1-157 | in isoform 9 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_059289 | 1-164 | in isoform 10 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_059288 | 1-265 | in isoform 7 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_059287 | 1-344 | in isoform 11 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_059286 | 1-368 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_059285 | 1-467 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 30-45 | Basic and acidic residues | ||||
Sequence: SKEEPAEQKNEVEEPD | ||||||
Compositional bias | 142-156 | Polar residues | ||||
Sequence: LLNESFASNPTDETV | ||||||
Compositional bias | 157-171 | Basic and acidic residues | ||||
Sequence: LMQKTKDEMDATSER | ||||||
Compositional bias | 174-201 | Pro residues | ||||
Sequence: SPLDLPPPPASVVLHPSAPPPPPPPLSS | ||||||
Compositional bias | 202-234 | Polar residues | ||||
Sequence: TEVVGNTTTTTTTHYAPKTWNDPSITTAPKIPV | ||||||
Compositional bias | 241-269 | Polar residues | ||||
Sequence: QPLPSVLTQRTTTSSYSAPNYSASSMSGV | ||||||
Compositional bias | 284-307 | Polar residues | ||||
Sequence: QSSSSAASYQHHHASSISKSISSS | ||||||
Compositional bias | 409-455 | Basic and acidic residues | ||||
Sequence: DGRTREEKTVDYKVTYHRDIEEQERRIREDQARRQQEEQDRRDREDN | ||||||
Compositional bias | 744-800 | Basic and acidic residues | ||||
Sequence: RKKEARDRDRLDEMERERVREEEERREKERREQERRIAAEKERKRRQEEEEEIARLN | ||||||
Compositional bias | 814-851 | Basic and acidic residues | ||||
Sequence: NAELDRQRQRDELDRKAQELSEREMREKERRDRERANE | ||||||
Compositional bias | 1008-1052 | Basic and acidic residues | ||||
Sequence: RYQRAKNEKARRDFYHSSQDSADPVTERFRKSTDDLTTRSRPEYR | ||||||
Alternative sequence | VSP_059294 | 1088-1128 | in isoform 8 | |||
Sequence: Missing | ||||||
Compositional bias | 1136-1198 | Basic and acidic residues | ||||
Sequence: ESVVAYERESRRESPADQAHIRSRSADYLMDRRIREETEVPENQLQKTRVEPHDQSPRESRIS | ||||||
Compositional bias | 1295-1315 | Polar residues | ||||
Sequence: SLHQTGQQETSNRQGSTLSVG |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284606 EMBL· GenBank· DDBJ | SBV53382.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | CCD62273.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | SBV53392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | SBV53384.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | SBV53383.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | SBV53380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | SBV53390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | CCD62272.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | SBV53381.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | CCD62269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284606 EMBL· GenBank· DDBJ | SBV53391.1 EMBL· GenBank· DDBJ | Genomic DNA |