A0A1C3D2N5 · A0A1C3D2N5_GEOTH
- ProteinGlycerol-3-phosphate dehydrogenase [NAD(P)+]
- GenegpsA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids344 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Catalytic activity
- sn-glycerol 3-phosphate + NAD+ = dihydroxyacetone phosphate + NADH + H+
Pathway
Membrane lipid metabolism; glycerophospholipid metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 12 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 32 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 33 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 49 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 106 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 106 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 136 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 138 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 140 | NADPH (UniProtKB | ChEBI) | |||
Active site | 192 | Proton acceptor | |||
Binding site | 192 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 245 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 255 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 256 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 256 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 257 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 280 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 282 | NADPH (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glycerol-3-phosphate dehydrogenase (NADP+) activity | |
Molecular Function | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity | |
Molecular Function | NAD binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | glycerol-3-phosphate biosynthetic process | |
Biological Process | glycerol-3-phosphate catabolic process | |
Biological Process | glycerophospholipid metabolic process | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol-3-phosphate dehydrogenase [NAD(P)+]
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Geobacillus > Geobacillus thermoleovorans group
Accessions
- Primary accessionA0A1C3D2N5
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length344
- Mass (Da)36,831
- Last updated2017-01-18 v1
- MD5 Checksum8B0EFDCF4074B2E6935938EBF8DE9404
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP027303 EMBL· GenBank· DDBJ | AWO75631.1 EMBL· GenBank· DDBJ | Genomic DNA |