A0A1C2D5N1 · A0A1C2D5N1_9LACO

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

138150100150200250300350
Type
IDPosition(s)Description
Binding site29Mg2+ (UniProtKB | ChEBI)
Site34Substrate discrimination
Binding site129Mg2+ (UniProtKB | ChEBI)
Active site130

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA-templated DNA replication
Biological Processerror-prone translesion synthesis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB
    • ORF names
      F1C01_02370
      , F1C09_05300
      , F8251_03055
      , GTO85_02175

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • NCK2488
    • NCK971
    • BIO6272
    • 1D
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A1C2D5N1
  • Secondary accessions
    • A0A6P1TXP0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-211UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    381
  • Mass (Da)
    43,369
  • Last updated
    2016-11-02 v1
  • Checksum
    D0C606C9064966C1
MSHQLNIGFMNKENLLPQNDIHRRIIHLDMDAFYASVEMQEHPEWKNKALIVGQDPRQNGGHGVVATCNYVARKYGVHSAMAAIQAVRLVPKELIVFTRPRFDKYRAVSAKIHSFMHDVTDQVESVALDEAYLDVTHPKIEQESAVQIALDLQKRIRQEVGLNSSFGVSYNKFLAKMGSEYAKPFGRTVILPSEVQNFLAMQKIEKFPGIGPKTQEELHQMGVYTGADLQKVEVLTLIKKFKKMGYILAQHARGIDLRPVVTDSEANRKSIGMERTYEPAIYTEDEALTNIRNYCNHLEAALKKRNFKAGTVVIKVRNNNFDTVTKRKKLKTPSDSHLDFYDVARDLFEATSSFLDDGIRLLGVTVTDFEKKKYQSISLFD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VYYV01000001
EMBL· GenBank· DDBJ
KAA8780795.1
EMBL· GenBank· DDBJ
Genomic DNA
VUAV01000024
EMBL· GenBank· DDBJ
KAA8812664.1
EMBL· GenBank· DDBJ
Genomic DNA
WBOB01000009
EMBL· GenBank· DDBJ
KAB1977535.1
EMBL· GenBank· DDBJ
Genomic DNA
CP047415
EMBL· GenBank· DDBJ
QLL73294.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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