A0A1B9IKZ8 · A0A1B9IKZ8_9TREE
- ProteinDecapping nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids389 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Catalytic activity
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N7-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H+This reaction proceeds in the forward direction.
- a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD+ + H+This reaction proceeds in the forward direction.
- a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | mRNA 5'-diphosphatase activity | |
Molecular Function | nuclease activity | |
Molecular Function | nucleotide binding | |
Molecular Function | RNA binding | |
Biological Process | NAD-cap decapping | |
Biological Process | nuclear-transcribed mRNA catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDecapping nuclease
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Kwoniella
Accessions
- Primary accessionA0A1B9IKZ8
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-24 | Disordered | |||
Domain | 25-379 | RAI1-like | |||
Sequence similarities
Belongs to the DXO/Dom3Z family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length389
- Mass (Da)44,071
- Last updated2016-11-02 v1
- MD5 Checksum5C7AA15060EB50D1F9CFA3766327E77F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV700091 EMBL· GenBank· DDBJ | OCF56306.1 EMBL· GenBank· DDBJ | Genomic DNA |