A0A1B8J846 · A0A1B8J846_9HELI

  • Protein
    Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
  • Gene
    bioA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.

Features

Showing features for site, binding site.

TypeIDPosition(s)Description
Site69Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Binding site106substrate
Binding site166-167pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site227substrate
Binding site351pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site380substrate
Binding site415substrate
Binding site416-417pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site588substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenosylmethionine-8-amino-7-oxononanoate transaminase activity
Molecular Functionpyridoxal phosphate binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
  • EC number
  • Alternative names
    • 7,8-diamino-pelargonic acid aminotransferase
      (DAPA AT
      ; DAPA aminotransferase
      )
    • 7,8-diaminononanoate synthase
      (DANS
      )
    • Diaminopelargonic acid synthase

Gene names

    • Name
      bioA
    • ORF names
      BA723_06625
      , BKN38_08630

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • HMC1
    • CLO-3
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter

Accessions

  • Primary accession
    A0A1B8J846

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue380N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-52Disordered
Compositional bias7-25Basic and acidic residues
Compositional bias33-51Basic and acidic residues
Region528-568Disordered
Compositional bias542-563Polar residues

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    621
  • Mass (Da)
    69,099
  • Last updated
    2016-11-02 v1
  • Checksum
    9239085D434E54BA
MKKNQAKTVTKLLESKRDKKSRQKSQNLSAPKSHDKTTKKPKSRDKATKMPKTNRALSALDLAHIWHPCTQMQEHEDLALIPIARAKGVYLYDFDGNSYIDGISSWWVNLFGHGNKRINKAITKQLSNLEHVLLAGFTHEPIIRLSTRLCEKLPPKLEKCFYADNGSSAIEVALKMSFHYHSLRDFDLRDFDLQDSDLQAESSLKKSAPKQALRKKRTKFLALENAYHGETLGALSVGDVELYKKTYEPLLLECITTPVPKSYNITSARESKSAPHAMQTTFTPANLDSSAYFQKELDALESILQAHGDEICAFILEPLVQCAGEMNMYPRGFIKRACEMCAKRGIHIIFDEIAVGFGRTGSMFALESCGVTPDFLCLSKGITGGYMPLSVVITSQEIYSAFYAPYEAGRAFLHSHSYTGNALACSAANAVLDIFEKEDIIARNAKLAESIAAQWCSIANIKSIAHKVRNIRHCGMIFALDIVGENITNREIIGHRGELDSEALESKELDFGVLESAKIDSANLDSRAPKSAKLDSGAQKGGLESATAQTTRQKSPQKSSPKSPKKAPQKRLGLFIFEQALKRGVLLRPLGSTIYFMPPFTISKKQARYVIRQIIEILEMI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias7-25Basic and acidic residues
Compositional bias33-51Basic and acidic residues
Compositional bias542-563Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MAMQ01000074
EMBL· GenBank· DDBJ
OBV29138.1
EMBL· GenBank· DDBJ
Genomic DNA
MLQN01000036
EMBL· GenBank· DDBJ
OHU81639.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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