A0A1B8J7N5 · A0A1B8J7N5_9HELI
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids162 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11 | substrate | ||||
Sequence: T | ||||||
Binding site | 11-12 | ATP (UniProtKB | ChEBI) | ||||
Sequence: TF | ||||||
Binding site | 19 | ATP (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 19 | Transition state stabilizer | ||||
Sequence: H | ||||||
Binding site | 43 | substrate | ||||
Sequence: K | ||||||
Binding site | 75 | substrate | ||||
Sequence: L | ||||||
Binding site | 89 | substrate | ||||
Sequence: R | ||||||
Binding site | 90-92 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GLR | ||||||
Binding site | 100 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 125-131 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NAFISSS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionA0A1B8J7N5
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-135 | Cytidyltransferase-like | ||||
Sequence: IYPGTFDPLTNGHLDIIKRSCEIFDNVILAIAHSASKQPLFSIEERLEMARLVTSDFDNVCCIEFGGLLADLAKEYNAKILIRGLRVVSDFEYELQMGYTNTSLNPELDTIYFMPTLQNAFISSSIVRN |
Sequence similarities
Belongs to the bacterial CoaD family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length162
- Mass (Da)18,262
- Last updated2016-11-02 v1
- Checksum08D4D132FB944943
Keywords
- Technical term