A0A1B8J6L5 · A0A1B8J6L5_9HELI
- ProteinBiotin carboxylase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids472 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
Catalytic activity
- ATP + hydrogencarbonate + N6-biotinyl-L-lysyl-[protein] = ADP + H+ + N6-carboxybiotinyl-L-lysyl-[protein] + phosphate
Pathway
Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | acetyl-CoA carboxylase activity | |
Molecular Function | ATP binding | |
Molecular Function | biotin carboxylase activity | |
Molecular Function | metal ion binding | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | malonyl-CoA biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBiotin carboxylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionA0A1B8J6L5
Proteomes
Interaction
Subunit
Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-466 | Biotin carboxylation | ||||
Sequence: KIERILIANRGEIALRAIRTIQEMGKQAIAIYSVADKDTHYLDVADAKVCIGGAKSSESYLNIPAIMSAATLFDADAIFPGYGFLSENQHFVEICSHHGIEFIGPSSEVMVMMSDKSKAKDVMKDAGVPVIMGSDGALKDANHAIEVAKTIGYPVILKAAAGGGGRGMRIVEKESMLKNLYLAAESEALSAFGDGTIYMEKFINKPKHIEVQILADKHGNVLHIGERDCSAQRRQQKLIEETPAVVLSPEVRENLLKTAVKAAKHIGYVGAGTFEFLLDSNNKDFYFMEMNTRLQVEHTVSEMVSGLDLIEWMIRIAEGEELPSQDSITFRGHSIECRITAEDPVRFYPSAGKITQWIAPGGANVRLDSHAYAGYVVPMFYDSMIGKLIVWGEDRKRAIARMKRALREFSVEGIKTTIPFHIKMMDNVDFLNSKIHTKFLEQDLE | ||||||
Domain | 141-339 | ATP-grasp | ||||
Sequence: KDVMKDAGVPVIMGSDGALKDANHAIEVAKTIGYPVILKAAAGGGGRGMRIVEKESMLKNLYLAAESEALSAFGDGTIYMEKFINKPKHIEVQILADKHGNVLHIGERDCSAQRRQQKLIEETPAVVLSPEVRENLLKTAVKAAKHIGYVGAGTFEFLLDSNNKDFYFMEMNTRLQVEHTVSEMVSGLDLIEWMIRIAE |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length472
- Mass (Da)52,300
- Last updated2016-11-02 v1
- ChecksumBCCC9966AB1DE5E8
Keywords
- Technical term