A0A1B8DFJ4 · A0A1B8DFJ4_9PEZI
- ProteinCatalase-peroxidase
- GenekatG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids794 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H2O2 in hyphae. May play an antioxidative role in fungal defense against the host-produced H2O2 (oxidative burst) at the early stage of plant infection.
Catalytic activity
- 2 H2O2 = O2 + 2 H2O
Cofactor
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.
Features
Showing features for site, active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 144 | Transition state stabilizer | |||
Active site | 148 | Proton acceptor | |||
Binding site | 323 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | extracellular region | |
Molecular Function | catalase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to hydrogen peroxide | |
Biological Process | hydrogen peroxide catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCatalase-peroxidase
- EC number
- Short namesCP
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Thelebolales > Thelebolaceae > Pseudogymnoascus
Accessions
- Primary accessionA0A1B8DFJ4
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, cross-link.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-23 | ||||
Chain | PRO_5008447948 | 24-794 | Catalase-peroxidase | ||
Cross-link | 282↔308 | Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-147) | |||
Post-translational modification
Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 47-74 | Disordered | |||
Domain | 142-467 | Plant heme peroxidase family profile | |||
Sequence similarities
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length794
- Mass (Da)86,988
- Last updated2016-11-02 v1
- ChecksumE9DB7B71A6F17FFA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV456018 EMBL· GenBank· DDBJ | OBT57928.1 EMBL· GenBank· DDBJ | Genomic DNA |