A0A1B7YL49 · A0A1B7YL49_COLHI

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site3Mg2+ (UniProtKB | ChEBI)
Binding site3-5GTP (UniProtKB | ChEBI)
Active site4Proton donor
Binding site93IMP (UniProtKB | ChEBI)
Binding site107IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site185IMP (UniProtKB | ChEBI)
Binding site200IMP (UniProtKB | ChEBI)
Binding site260-266substrate
Binding site264IMP (UniProtKB | ChEBI)
Binding site266GTP (UniProtKB | ChEBI)
Binding site292-294GTP (UniProtKB | ChEBI)
Binding site376-378GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      CH63R_05056

Organism names

Accessions

  • Primary accession
    A0A1B7YL49

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    389
  • Mass (Da)
    43,058
  • Last updated
    2016-11-02 v1
  • Checksum
    8142E131A2281B7B
MSGHTVIANGVSYDFHLLPSGLLHQECISLIGSGAVVHVPTFFKEMADLEAKGLKNIRERLLVSDRCHIITDCHIQVDGLEEQELGGNSIGTTKRGIGPTYSTMAARNGITISEMFDEEVFARKLRQLAQGFKKRFGDLLVYDVEDEITRFKQYREDLRTFVVDAVPIIADAQKNGNKILVEGAQAVMLDLNFGTYPYVTSSNTGLGGVFTGLGLNPKKINNIVGVVKSYTTRVGGGGFPTELLNETGEKLQKIGHEIGVSTGRSRRCGWLDLVVIKYSTDLNHYTALNLTKLDILDSFPTIKVAVAYKNKHTGEQFASFPADLKALEDAEVVYEEFEGWNTPTTGAKTFYDLPKQARAYVEFIEKFVGVKVVWIGTGPKREDLIFRGY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LTAN01000003
EMBL· GenBank· DDBJ
OBR12760.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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