A0A1B7YDZ4 · SNX4_COLHI
- ProteinSorting nexin-4
- GeneATG24
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids478 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity).
Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy (PubMed:35835849).
Required for the switch to necrotrophic growth (PubMed:35835849).
Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy (PubMed:35835849).
Required for the switch to necrotrophic growth (PubMed:35835849).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 101 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | |||
Binding site | 103 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | |||
Binding site | 127 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | |||
Binding site | 146 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome | |
Cellular Component | lipid droplet | |
Cellular Component | membrane | |
Cellular Component | mitochondrion | |
Cellular Component | phagophore assembly site | |
Molecular Function | phosphatidylinositol binding | |
Biological Process | endocytic recycling | |
Biological Process | mitophagy | |
Biological Process | piecemeal microautophagy of the nucleus | |
Biological Process | protein transport | |
Biological Process | reticulophagy |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSorting nexin-4
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Glomerellales > Glomerellaceae > Colletotrichum > Colletotrichum destructivum species complex
Accessions
- Primary accessionA0A1B7YDZ4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Preautophagosomal structure membrane ; Peripheral membrane protein
Endosome membrane ; Peripheral membrane protein
Mitochondrion membrane ; Peripheral membrane protein
Note: Endosome and other perivacuolar punctate structures. Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures (By similarity).
Found at lipid droplets and mitochondria during nitrogen starvation (PubMed:35835849).
Found at lipid droplets and mitochondria during nitrogen starvation (PubMed:35835849).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000461188 | 1-478 | Sorting nexin-4 | ||
Expression
Induction
Induced during nitrogen starvation (at protein level).
Interaction
Subunit
Interacts with the mitochondrial prohibitin complex subunits PHB1 and PHB2; the interaction is direct and plays a role in mitophagy.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 58-180 | PX | |||
Domain
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence similarities
Belongs to the sorting nexin family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length478
- Mass (Da)54,454
- Last updated2016-11-02 v1
- Checksum046EC474F1EC2937
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LTAN01000004 EMBL· GenBank· DDBJ | OBR10242.1 EMBL· GenBank· DDBJ | Genomic DNA |