A0A1B7Y1P1 · A0A1B7Y1P1_COLHI
- ProteinGlutathione hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids575 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 108 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 386 | Nucleophile | ||||
Sequence: T | ||||||
Binding site | 404-406 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: TVN | ||||||
Binding site | 428 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 456-457 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: SS | ||||||
Binding site | 479 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | glutathione hydrolase activity | |
Molecular Function | leukotriene C4 gamma-glutamyl transferase activity | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Glomerellales > Glomerellaceae > Colletotrichum > Colletotrichum destructivum species complex
Accessions
- Primary accessionA0A1B7Y1P1
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MKPSSSHSTWRCYASLLLLAELRSTSA | ||||||
Chain | PRO_5008601270 | 28-575 | Glutathione hydrolase | |||
Sequence: ATVPQFVFNPHAGSSGAVASEAVECSKIGRDLIARGGNAVDALVGTTFCVGTVGMYHSGIGGGGFVVVRDAYGNYESVDFRESAPAAAFQDMYKGNIEGSVYGGLAVGVPSEVRGLEYIHKKYGVLPWKAVVTPAAQLATTGFRVSEDLVRYMANAINGQYNFLVEDPVWAEEFAPNGKLLQLGDTIYRKRYGAHTSTLAKIAEEGPDAFYSGPIAESIIATVRATNGSLTLDDLSSYKVVTRPSLSISYRGHRLVSVGSPASGAVCLNTLKIMEQFDPSESADTHLGVHRFDEALRFAYGARSLLGDPDFVDGIGPFEDTLIDEATAKDIRHRILDNQTQPVDRYDPHGMYASEGFGTSHIVTADKSGMATSLTTTVNLLFGAQIMDPLSGVILNNEMNDFSIPGVRNAFGFEPSPANFVRANKRPLSSITPVIVEHPDGTLYATVGAAGGSRIISSTAQVAWHVLEHGRTMKQALREPRLHDQLMPNTVTFEYAFDNDTVASMIEKGHDVTWVPEGRSAVQGIIFDGGVFEAASEPRQKNSGAFTV |
Structure
Sequence
- Sequence statusComplete
- Length575
- Mass (Da)61,751
- Last updated2016-11-02 v1
- Checksum8DCA4BCA3A9AD7C9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LTAN01000007 EMBL· GenBank· DDBJ | OBR05935.1 EMBL· GenBank· DDBJ | Genomic DNA |