A0A1B4ZDL9 · A0A1B4ZDL9_9ACTN

  • Protein
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
  • Gene
    dapD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.

Features

Showing features for binding site, active site.

132750100150200250300
TypeIDPosition(s)Description
Binding site175Mg2+ 1 (UniProtKB | ChEBI); ligand shared between trimeric partners
Binding site192Mg2+ 2 (UniProtKB | ChEBI); ligand shared between trimeric partners
Active site208Acyl-anhydride intermediate
Binding site210succinyl-CoA (UniProtKB | ChEBI)
Binding site225succinyl-CoA (UniProtKB | ChEBI)
Binding site228succinyl-CoA (UniProtKB | ChEBI)
Binding site251succinyl-CoA (UniProtKB | ChEBI)
Binding site266-267succinyl-CoA (UniProtKB | ChEBI)
Binding site274succinyl-CoA (UniProtKB | ChEBI)
Binding site286succinyl-CoA (UniProtKB | ChEBI)
Binding site299-302succinyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
Molecular Functionmagnesium ion binding
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
  • EC number
  • Alternative names
    • Tetrahydrodipicolinate N-succinyltransferase
      (THDP succinyltransferase
      ; THP succinyltransferase
      )
    • Tetrahydropicolinate succinylase

Gene names

    • Name
      dapD

Organism names

  • Taxonomic identifier
  • Strain
    • SANK 60404
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A1B4ZDL9

Subcellular Location

Keywords

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain119-1592,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    327
  • Mass (Da)
    33,642
  • Last updated
    2016-11-02 v1
  • Checksum
    17CBD8641DB63715
MTSAPRTTGAVAAGLATIAGDGTVLDTWFPAPELVAEPGPAGTERLTSDQAVNLLGEGAAKAVGVDARRGVEVVAVRTVIASLDEKPLDAHDAYLRLHLLSHRLVKPHGQNLDGIFGLLANVAWTSLGPVAVDDVEKVRLNARAEGLHLQVTSIDKFPRMTDYVAPKGVRIADADRVRLGAHLAAGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVIGDGSDIGGGASTMGTLSGGGNVIISVGERCLIGAEAGVGIALGDECVVEAGLYITAGTRVTMPDGQIVKARELSGASNILFRRNSVTGTVEARPNNAVWGGLNDILHSHN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC163894
EMBL· GenBank· DDBJ
BAV57524.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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