A0A1B4WR98 · A0A1B4WR98_9BIVA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Euheterodonta > Imparidentia > Neoheterodontei > Venerida > Glossoidea > Vesicomyidae > Abyssogena

Accessions

  • Primary accession
    A0A1B4WR98

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane33-52Helical
Transmembrane72-95Helical
Transmembrane116-134Helical
Transmembrane161-182Helical
Transmembrane194-219Helical
Transmembrane259-277Helical
Transmembrane289-307Helical
Transmembrane319-341Helical
Transmembrane353-375Helical
Transmembrane387-409Helical
Transmembrane430-452Helical
Transmembrane472-489Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-535Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    550
  • Mass (Da)
    61,826
  • Last updated
    2016-11-02 v1
  • Checksum
    85430F9E9ED427AC
MWSFSGSTSVPFYKRSVIRRWLFSSNHKDIGTLYFFFSIWAGLMGTAFSIIIRFELAMPGAGVLGDSHLYQVVVTAHGLLMIFFLVMPMMIGGFGNWLVPLMLQIPDMAFPRMNNLSFWLMPSSVLMLLGSAYVESGAGTGWTIYPPLSSIMGHAGPSVDFVILSLHLGGVSSILASINFVVTSLCMRVEALSLLRVTMFVWCVAITGFLLIIAMPVLAGSLTMLLTDRNFNTSFFDPAGLGDPILFVHLFWFFGHPEVYILILPGFGIISHVIKVGSSKLELFGKVPMIYAVLSIGFLGFIVWGHHMFTVGMNVDSRAYFSTVTLIIAIPTGVKVFSWLATMSGGYVRWWPMMYWAMGFLFLFTVGGITGIVLASASLDVMMHDSYYVIAHFHYVLSMGAVFSLFAGFHFWYPMVTGLGLHPLWSRGQFWTMFIGVNVTFFPQHLMGLLGMPRRYSDYSDSLHGLNLLSSWGSTVSLVSLFTFLFIIWESMLSQRCLVFPLVYGTEAEWSFRGYPLRFHNRSQNSFGFNAKDIKKKLLWWMKMDRHSSV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP014557
EMBL· GenBank· DDBJ
BAV25022.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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