A0A1B4PQX5 · A0A1B4PQX5_BURCE

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

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Type
IDPosition(s)Description
Binding site194-201ATP (UniProtKB | ChEBI)
Binding site416Zn2+ (UniProtKB | ChEBI); catalytic
Active site417
Binding site420Zn2+ (UniProtKB | ChEBI); catalytic
Binding site492Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      WT26_09765

Organism names

  • Taxonomic identifier
  • Strain
    • MSMB1184WGS
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Accessions

  • Primary accession
    A0A1B4PQX5

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane104-121Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain186-325AAA+ ATPase
Region588-631Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    631
  • Mass (Da)
    68,915
  • Last updated
    2016-11-02 v1
  • Checksum
    BD16E9C3B61E933C
MNNNMFSKAAVWLVIALVLFTVFKQFDKPRVQEGVSYSQFMDDAKNGKVKNVIVQGRNLTVTPADGQKYQIVSPGDIWMVGDLMKYGVQVSGKADDEPNALMSALYYLGPTILIIVFWFYMMRQMQGGGKGGAFSFGKSRARLIDENNNAVNFSDVAGCDEAKEEVSELVDFLRDPQKFQKLGGRIPRGVLLVGPPGTGKTLLARAIAGEAKVPFFSISGSDFVEMFVGVGAARVRDMFEQAKKHAPCIVFIDEIDAVGRHRGAGMGGGNDEREQTLNQMLVEMDGFEANSGVIVIAATNRSDVLDKALLRPGRFDRQVYVGLPDIRGREQIMRVHLRKVPIANDVDAAVIARGTPGFSGADLANLVNEAALFAARRGKRIVEMQDFEDAKDKIFMGPERKSAVIREEAKRATAYHESGHAVIAKLLPKADPVHKVTIIPRGRALGVTWQLPEHDNETYSKDYLLDRLAILFGGRVAEELFMNLVSTGASDDFNKATQTARAMVARFGMTDALGPMVYVDDENDASPFGRGFTRTISEATQQKVDSEIRRVLDEQYGLARRLLEENRDKVEAMTAALMEWETIDADQINDIMEGRPPRSPKSSPAVGGDASSGGTGAEVKPGNAPAPASPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP013443
EMBL· GenBank· DDBJ
AOK16277.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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