A0A1B2BGF9 · A0A1B2BGF9_TRIGR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • RS10.1
    • RS10.2
    • RS4.1
    • RS4.2
    • RS6.1
  • Taxonomic lineage
    Eukaryota > Metazoa > Echinodermata > Eleutherozoa > Echinozoa > Echinoidea > Euechinoidea > Echinacea > Temnopleuroida > Toxopneustidae > Tripneustes

Accessions

  • Primary accession
    A0A1B2BGF9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-53Helical
Transmembrane74-98Helical
Transmembrane118-141Helical
Transmembrane153-180Helical
Transmembrane213-231Helical
Transmembrane238-261Helical
Transmembrane273-296Helical
Transmembrane308-329Helical
Transmembrane349-370Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-375Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    375
  • Mass (Da)
    40,982
  • Last updated
    2016-11-02 v1
  • Checksum
    C35C32B1DECE3A09
TAMSVIIRAELAQPGSLLNDDQIYNVVVTAHALVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLVPPSFILLLASAGVESGAGTGWTIYPPLSSNIAHAGGSVDLAIFSLHLAGASSILASINFITTIINMRTPGMSFDRLPLFVWSVFVTAFLLLLSLPVLAGAITMLLTDRNINTTFFDPAGGGDPILFQHLFWFFGHPEVYILILPGFGMISHVIAHYSGKREPFGYLGMVYAMIAIGILGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWMATLQGSNLQWETPLLWALGFVFLFTLGGLTGIVLANSSIDVVLHDTYYVVAHFHYVLSMGAVFAIFAGFTHWFPLFSGYNL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue375

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU314827
EMBL· GenBank· DDBJ
ANY39399.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314828
EMBL· GenBank· DDBJ
ANY39400.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314829
EMBL· GenBank· DDBJ
ANY39401.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314830
EMBL· GenBank· DDBJ
ANY39402.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314831
EMBL· GenBank· DDBJ
ANY39403.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314832
EMBL· GenBank· DDBJ
ANY39404.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314833
EMBL· GenBank· DDBJ
ANY39405.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314834
EMBL· GenBank· DDBJ
ANY39406.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314835
EMBL· GenBank· DDBJ
ANY39407.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314836
EMBL· GenBank· DDBJ
ANY39408.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314837
EMBL· GenBank· DDBJ
ANY39409.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314838
EMBL· GenBank· DDBJ
ANY39410.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314839
EMBL· GenBank· DDBJ
ANY39411.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314840
EMBL· GenBank· DDBJ
ANY39412.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314842
EMBL· GenBank· DDBJ
ANY39414.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314843
EMBL· GenBank· DDBJ
ANY39415.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314844
EMBL· GenBank· DDBJ
ANY39416.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314845
EMBL· GenBank· DDBJ
ANY39417.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314846
EMBL· GenBank· DDBJ
ANY39418.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314847
EMBL· GenBank· DDBJ
ANY39419.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314848
EMBL· GenBank· DDBJ
ANY39420.1
EMBL· GenBank· DDBJ
Genomic DNA
KU314849
EMBL· GenBank· DDBJ
ANY39421.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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