A0A1B2BGF9 · A0A1B2BGF9_TRIGR
- ProteinCytochrome c oxidase subunit 1
- Genecox1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids375 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Echinodermata > Eleutherozoa > Echinozoa > Echinoidea > Euechinoidea > Echinacea > Temnopleuroida > Toxopneustidae > Tripneustes
Accessions
- Primary accessionA0A1B2BGF9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 23-53 | Helical | |||
Transmembrane | 74-98 | Helical | |||
Transmembrane | 118-141 | Helical | |||
Transmembrane | 153-180 | Helical | |||
Transmembrane | 213-231 | Helical | |||
Transmembrane | 238-261 | Helical | |||
Transmembrane | 273-296 | Helical | |||
Transmembrane | 308-329 | Helical | |||
Transmembrane | 349-370 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length375
- Mass (Da)40,982
- Last updated2016-11-02 v1
- ChecksumC35C32B1DECE3A09
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 375 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KU314827 EMBL· GenBank· DDBJ | ANY39399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314828 EMBL· GenBank· DDBJ | ANY39400.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314829 EMBL· GenBank· DDBJ | ANY39401.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314830 EMBL· GenBank· DDBJ | ANY39402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314831 EMBL· GenBank· DDBJ | ANY39403.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314832 EMBL· GenBank· DDBJ | ANY39404.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314833 EMBL· GenBank· DDBJ | ANY39405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314834 EMBL· GenBank· DDBJ | ANY39406.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314835 EMBL· GenBank· DDBJ | ANY39407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314836 EMBL· GenBank· DDBJ | ANY39408.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314837 EMBL· GenBank· DDBJ | ANY39409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314838 EMBL· GenBank· DDBJ | ANY39410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314839 EMBL· GenBank· DDBJ | ANY39411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314840 EMBL· GenBank· DDBJ | ANY39412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314842 EMBL· GenBank· DDBJ | ANY39414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314843 EMBL· GenBank· DDBJ | ANY39415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314844 EMBL· GenBank· DDBJ | ANY39416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314845 EMBL· GenBank· DDBJ | ANY39417.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314846 EMBL· GenBank· DDBJ | ANY39418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314847 EMBL· GenBank· DDBJ | ANY39419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314848 EMBL· GenBank· DDBJ | ANY39420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU314849 EMBL· GenBank· DDBJ | ANY39421.1 EMBL· GenBank· DDBJ | Genomic DNA |