A0A1B2AIP4 · A0A1B2AIP4_CHIKV
- ProteinStructural polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1248 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 139 | Charge relay system | ||||
Sequence: H | ||||||
Active site | 161 | Charge relay system | ||||
Sequence: D | ||||||
Active site | 213 | Charge relay system | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell plasma membrane | |
Cellular Component | plasma membrane | |
Cellular Component | T=4 icosahedral viral capsid | |
Cellular Component | virion membrane | |
Molecular Function | serine-type endopeptidase activity | |
Molecular Function | structural molecule activity | |
Biological Process | fusion of virus membrane with host endosome membrane | |
Biological Process | proteolysis | |
Biological Process | symbiont entry into host cell | |
Biological Process | virion attachment to host cell |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameStructural polyprotein
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Alsuviricetes > Martellivirales > Togaviridae > Alphavirus
- Virus hosts
Accessions
- Primary accessionA0A1B2AIP4
Subcellular Location
UniProt Annotation
GO Annotation
Host cell membrane ; Multi-pass membrane protein
Host cell membrane ; Single-pass type I membrane protein
Virion membrane ; Multi-pass membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 687-715 | Helical | ||||
Sequence: LYPTMTVVVVSVASFILLSMVGVAVGMCM | ||||||
Transmembrane | 766-787 | Helical | ||||
Sequence: FWLQALIPLAALIVLCNCLRLL | ||||||
Transmembrane | 1226-1246 | Helical | ||||
Sequence: VGLVVAVAALILIVVLCVSFS |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Interacts with spike glycoprotein E1. Interacts with spike glycoprotein E2.
The precursor of protein E3/E2 and E1 form a heterodimer shortly after synthesis.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-40 | Disordered | ||||
Sequence: MEFIPTQTFYNRRYQPRPWTPRPTIQVIRPRPRPQRKAGQ | ||||||
Region | 52-104 | Disordered | ||||
Sequence: TMRVVPQQKPRKNRKNKKQKQKQQVPRNNMNQKKQPPKKKPVQKKKKPGRRER | ||||||
Compositional bias | 59-73 | Basic residues | ||||
Sequence: QKPRKNRKNKKQKQK | ||||||
Compositional bias | 84-102 | Basic residues | ||||
Sequence: KKQPPKKKPVQKKKKPGRR | ||||||
Domain | 113-261 | Peptidase S3 | ||||
Sequence: CIFEVKHEGKVTGYACLVGDKVMKPAHVKGTIDNADLAKLAFKRSSKYDLECAQIPVHMKSDASKFTHEKPEGYYNWHHGAVQYSGGRFTIPTGAGKPGDSGRPIFDNKGRVVAIVLGGANEGARTALSVVTWNKDIVTKITPEGAEEW |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,248
- Mass (Da)138,402
- Last updated2016-11-02 v1
- Checksum248006E37D7D1B09
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 59-73 | Basic residues | ||||
Sequence: QKPRKNRKNKKQKQK | ||||||
Compositional bias | 84-102 | Basic residues | ||||
Sequence: KKQPPKKKPVQKKKKPGRR |