A0A1B0TCJ0 · A0A1B0TCJ0_9TELE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      CO1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • V1-1
    • V1-10
    • V1-2
    • V1-3
    • V1-4
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Clupei > Clupeiformes > Clupeoidei > Clupeidae > Sardinella

Accessions

  • Primary accession
    A0A1B0TCJ0

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-52Helical
Transmembrane73-97Helical
Transmembrane117-140Helical
Transmembrane152-179Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-192Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    192
  • Mass (Da)
    20,453
  • Last updated
    2016-11-02 v1
  • MD5 Checksum
    6854986AA91A73ACF6CD7450604A479A
ALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue192

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT461702
EMBL· GenBank· DDBJ
ALI97309.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461703
EMBL· GenBank· DDBJ
ALI97310.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461704
EMBL· GenBank· DDBJ
ALI97311.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461705
EMBL· GenBank· DDBJ
ALI97312.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461706
EMBL· GenBank· DDBJ
ALI97313.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461707
EMBL· GenBank· DDBJ
ALI97314.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461708
EMBL· GenBank· DDBJ
ALI97315.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461709
EMBL· GenBank· DDBJ
ALI97316.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461710
EMBL· GenBank· DDBJ
ALI97317.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461711
EMBL· GenBank· DDBJ
ALI97318.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461712
EMBL· GenBank· DDBJ
ALI97319.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461713
EMBL· GenBank· DDBJ
ALI97320.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461714
EMBL· GenBank· DDBJ
ALI97321.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461715
EMBL· GenBank· DDBJ
ALI97322.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461716
EMBL· GenBank· DDBJ
ALI97323.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461717
EMBL· GenBank· DDBJ
ALI97324.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461718
EMBL· GenBank· DDBJ
ALI97325.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461719
EMBL· GenBank· DDBJ
ALI97326.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461721
EMBL· GenBank· DDBJ
ALI97328.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461722
EMBL· GenBank· DDBJ
ALI97329.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461723
EMBL· GenBank· DDBJ
ALI97330.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461724
EMBL· GenBank· DDBJ
ALI97331.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461725
EMBL· GenBank· DDBJ
ALI97332.1
EMBL· GenBank· DDBJ
Genomic DNA
KT461726
EMBL· GenBank· DDBJ
ALI97333.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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