A0A1B0GWA6 · A0A1B0GWA6_HUMAN
- ProteinSodium channel protein
- GeneSCN2A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1873 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | voltage-gated sodium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1B0GWA6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 119-139 | Helical | ||||
Sequence: VMILTVFCLSVFALIGLQLFM | ||||||
Transmembrane | 269-296 | Helical | ||||
Sequence: YMIFFVLVIFLGSFYLINLILAVVAMAY | ||||||
Transmembrane | 619-643 | Helical | ||||
Sequence: LVNLVVMDPFVDLAITICIVLNTLF | ||||||
Transmembrane | 655-676 | Helical | ||||
Sequence: FSSVLSVGNLVFTGIFTAEMFL | ||||||
Transmembrane | 738-766 | Helical | ||||
Sequence: LIKIIGNSVGALGNLTLVLAIIVFIFAVV | ||||||
Transmembrane | 828-851 | Helical | ||||
Sequence: LTVFMMVMVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1077-1095 | Helical | ||||
Sequence: WFETFIVFMILLSSGALAF | ||||||
Transmembrane | 1116-1138 | Helical | ||||
Sequence: VFTYIFILEMLLKWVAYGFQVYF | ||||||
Transmembrane | 1144-1164 | Helical | ||||
Sequence: WLDFLIVDVSLVSLTANALGY | ||||||
Transmembrane | 1193-1219 | Helical | ||||
Sequence: VVVNALLGAIPSIMNVLLVCLIFWLIF | ||||||
Transmembrane | 1317-1341 | Helical | ||||
Sequence: MYLYFVIFIIFGSFFTLNLFIGVII | ||||||
Transmembrane | 1400-1418 | Helical | ||||
Sequence: VFDISIMILICLNMVTMMV | ||||||
Transmembrane | 1430-1448 | Helical | ||||
Sequence: ILYWINLVFIVLFTGECVL | ||||||
Transmembrane | 1455-1480 | Helical | ||||
Sequence: YYYFTIGWNIFDFVVVILSIVGMFLA | ||||||
Transmembrane | 1517-1545 | Helical | ||||
Sequence: LLFALMMSLPALFNIGLLLFLVMFIYAIF | ||||||
Transmembrane | 1621-1644 | Helical | ||||
Sequence: IFFFVSYIIISFLVVVNMYIAVIL |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,585 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-17 | UniProt | |||||
Sequence: MLIMCTILTNCVFMTMS | |||||||
Chain | PRO_5008408685 | 18-1873 | UniProt | Sodium channel protein | |||
Sequence: NPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK | |||||||
Modified residue (large scale data) | 396 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 422 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-302 | Ion transport | ||||
Sequence: MLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQA | ||||||
Coiled coil | 293-338 | |||||
Sequence: AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAE | ||||||
Region | 362-397 | Disordered | ||||
Sequence: SSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESE | ||||||
Compositional bias | 378-397 | Basic and acidic residues | ||||
Sequence: QKEQSGEEEKNDRVRKSESE | ||||||
Domain | 426-577 | Voltage-gated Na+ ion channel cytoplasmic | ||||
Sequence: SLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIAS | ||||||
Region | 458-478 | Disordered | ||||
Sequence: ENDFADDEHSTFEDNDSRRDS | ||||||
Domain | 627-858 | Ion transport | ||||
Sequence: PFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDN | ||||||
Domain | 865-1071 | Sodium ion transport-associated | ||||
Sequence: DNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYK | ||||||
Region | 988-1033 | Disordered | ||||
Sequence: EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESL | ||||||
Domain | 1075-1350 | Ion transport | ||||
Sequence: HNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK | ||||||
Domain | 1399-1654 | Ion transport | ||||
Sequence: QVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEES | ||||||
Compositional bias | 1803-1827 | Basic and acidic residues | ||||
Sequence: DKGKECDGTPIKEDTLIDKLNENST | ||||||
Region | 1803-1873 | Disordered | ||||
Sequence: DKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK | ||||||
Compositional bias | 1828-1845 | Polar residues | ||||
Sequence: PEKTDMTPSTTSPPSYDS | ||||||
Compositional bias | 1846-1873 | Basic and acidic residues | ||||
Sequence: VTKPEKEKFEKDKSEKEDKGKDIRESKK |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,873
- Mass (Da)213,092
- Last updated2016-10-05 v1
- ChecksumAD64317B97765F6C
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q99250 | SCN2A_HUMAN | SCN2A | 2005 | ||
A0A1B0GTS6 | A0A1B0GTS6_HUMAN | SCN2A | 558 | ||
A0A1B0GTX0 | A0A1B0GTX0_HUMAN | SCN2A | 92 | ||
A0A1B0GW40 | A0A1B0GW40_HUMAN | SCN2A | 731 | ||
A0A1B0GW67 | A0A1B0GW67_HUMAN | SCN2A | 730 | ||
A0A0D9SGG2 | A0A0D9SGG2_HUMAN | SCN2A | 178 | ||
A0A669KBL5 | A0A669KBL5_HUMAN | SCN2A | 130 | ||
A0A669KBM3 | A0A669KBM3_HUMAN | SCN2A | 140 | ||
A0A669KAR0 | A0A669KAR0_HUMAN | SCN2A | 418 | ||
F6U291 | F6U291_HUMAN | SCN2A | 505 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 378-397 | Basic and acidic residues | ||||
Sequence: QKEQSGEEEKNDRVRKSESE | ||||||
Compositional bias | 1803-1827 | Basic and acidic residues | ||||
Sequence: DKGKECDGTPIKEDTLIDKLNENST | ||||||
Compositional bias | 1828-1845 | Polar residues | ||||
Sequence: PEKTDMTPSTTSPPSYDS | ||||||
Compositional bias | 1846-1873 | Basic and acidic residues | ||||
Sequence: VTKPEKEKFEKDKSEKEDKGKDIRESKK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC011303 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC013438 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC013463 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |