A0A1B0GVH2 · A0A1B0GVH2_HUMAN
- ProteinNeuronal acetylcholine receptor subunit alpha-7
- GeneCHRNA7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids440 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | postsynaptic membrane | |
Molecular Function | acetylcholine-gated monoatomic cation-selective channel activity | |
Molecular Function | transmembrane signaling receptor activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNeuronal acetylcholine receptor subunit alpha-7
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1B0GVH2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Postsynaptic cell membrane ; Multi-pass membrane protein
Synaptic cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 169-194 | Helical | ||||
Sequence: LYYGLNLLIPCVLISALALLVFLLPA | ||||||
Transmembrane | 200-218 | Helical | ||||
Sequence: ISLGITVLLSLTVFMLLVA | ||||||
Transmembrane | 230-253 | Helical | ||||
Sequence: LIAQYFASTMIIVGLSVVVTVIVL | ||||||
Transmembrane | 408-428 | Helical | ||||
Sequence: LCLMAFSVFTIICTIGILMSA |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 515 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-168 | Neurotransmitter-gated ion-channel ligand-binding | ||||
Sequence: DVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRT | ||||||
Domain | 175-424 | Neurotransmitter-gated ion-channel transmembrane | ||||
Sequence: LLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGI |
Sequence similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length440
- Mass (Da)49,463
- Last updated2016-10-05 v1
- Checksum9CA1C88012F4A533
Computationally mapped potential isoform sequences
There are 20 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P36544 | ACHA7_HUMAN | CHRNA7 | 502 | ||
A0A1B0GV86 | A0A1B0GV86_HUMAN | CHRNA7 | 221 | ||
A0A1B0GUR5 | A0A1B0GUR5_HUMAN | CHRNA7 | 231 | ||
A0A1B0GV25 | A0A1B0GV25_HUMAN | CHRNA7 | 302 | ||
A0A1B0GV43 | A0A1B0GV43_HUMAN | CHRNA7 | 423 | ||
A0A1B0GV44 | A0A1B0GV44_HUMAN | CHRNA7 | 291 | ||
A0A1B0GTT0 | A0A1B0GTT0_HUMAN | CHRNA7 | 40 | ||
A0A1B0GTT9 | A0A1B0GTT9_HUMAN | CHRNA7 | 318 | ||
A0A1B0GU56 | A0A1B0GU56_HUMAN | CHRNA7 | 132 | ||
A0A1B0GU93 | A0A1B0GU93_HUMAN | CHRNA7 | 93 | ||
A0A1B0GU04 | A0A1B0GU04_HUMAN | CHRNA7 | 180 | ||
A0A1B0GU11 | A0A1B0GU11_HUMAN | CHRNA7 | 160 | ||
A0A1B0GTE0 | A0A1B0GTE0_HUMAN | CHRNA7 | 84 | ||
A0A1B0GWH1 | A0A1B0GWH1_HUMAN | CHRNA7 | 81 | ||
A0A1B0GVN6 | A0A1B0GVN6_HUMAN | CHRNA7 | 71 | ||
A0A1B0GVP9 | A0A1B0GVP9_HUMAN | CHRNA7 | 81 | ||
A0A1B0GW47 | A0A1B0GW47_HUMAN | CHRNA7 | 284 | ||
A0A1B0GW52 | A0A1B0GW52_HUMAN | CHRNA7 | 210 | ||
A0A1B0GVI5 | A0A1B0GVI5_HUMAN | CHRNA7 | 159 | ||
A0A1W2PN81 | A0A1W2PN81_HUMAN | CHRNA7 | 502 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ABBA01038340 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC058803 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC068448 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC079969 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF456018 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF456023 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF573652 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |