A0A1B0GVH2 · A0A1B0GVH2_HUMAN

  • Protein
    Neuronal acetylcholine receptor subunit alpha-7
  • Gene
    CHRNA7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentpostsynaptic membrane
Molecular Functionacetylcholine-gated monoatomic cation-selective channel activity
Molecular Functiontransmembrane signaling receptor activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuronal acetylcholine receptor subunit alpha-7

Gene names

    • Name
      CHRNA7

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1B0GVH2

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Postsynaptic cell membrane
; Multi-pass membrane protein
Synaptic cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane169-194Helical
Transmembrane200-218Helical
Transmembrane230-253Helical
Transmembrane408-428Helical

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 515 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-168Neurotransmitter-gated ion-channel ligand-binding
Domain175-424Neurotransmitter-gated ion-channel transmembrane

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    440
  • Mass (Da)
    49,463
  • Last updated
    2016-10-05 v1
  • Checksum
    9CA1C88012F4A533
MDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA

Computationally mapped potential isoform sequences

There are 20 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P36544ACHA7_HUMANCHRNA7502
A0A1B0GV86A0A1B0GV86_HUMANCHRNA7221
A0A1B0GUR5A0A1B0GUR5_HUMANCHRNA7231
A0A1B0GV25A0A1B0GV25_HUMANCHRNA7302
A0A1B0GV43A0A1B0GV43_HUMANCHRNA7423
A0A1B0GV44A0A1B0GV44_HUMANCHRNA7291
A0A1B0GTT0A0A1B0GTT0_HUMANCHRNA740
A0A1B0GTT9A0A1B0GTT9_HUMANCHRNA7318
A0A1B0GU56A0A1B0GU56_HUMANCHRNA7132
A0A1B0GU93A0A1B0GU93_HUMANCHRNA793
A0A1B0GU04A0A1B0GU04_HUMANCHRNA7180
A0A1B0GU11A0A1B0GU11_HUMANCHRNA7160
A0A1B0GTE0A0A1B0GTE0_HUMANCHRNA784
A0A1B0GWH1A0A1B0GWH1_HUMANCHRNA781
A0A1B0GVN6A0A1B0GVN6_HUMANCHRNA771
A0A1B0GVP9A0A1B0GVP9_HUMANCHRNA781
A0A1B0GW47A0A1B0GW47_HUMANCHRNA7284
A0A1B0GW52A0A1B0GW52_HUMANCHRNA7210
A0A1B0GVI5A0A1B0GVI5_HUMANCHRNA7159
A0A1W2PN81A0A1W2PN81_HUMANCHRNA7502

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ABBA01038340
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC058803
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC068448
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC079969
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456018
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456023
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF573652
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp