A0A1B0GVG2 · A0A1B0GVG2_HUMAN
- ProteinAcid ceramidase
- GeneASAH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids341 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine
Pathway
Lipid metabolism; sphingolipid metabolism.
Sphingolipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 159 | Nucleophile | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | lysosome | |
Molecular Function | ceramidase activity | |
Molecular Function | fatty acid amide hydrolase activity | |
Molecular Function | N-acylsphingosine amidohydrolase activity | |
Biological Process | fatty acid metabolic process | |
Biological Process | sphingolipid metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAcid ceramidase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1B0GVG2
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 566 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Heterodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 61-123 | Acid ceramidase N-terminal | ||||
Sequence: GAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGN | ||||||
Domain | 159-322 | Choloylglycine hydrolase/NAAA C-terminal | ||||
Sequence: CTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYE |
Sequence similarities
Belongs to the acid ceramidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length341
- Mass (Da)38,015
- Last updated2016-10-05 v1
- ChecksumD8B7B603E92B89F5
Computationally mapped potential isoform sequences
There are 37 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q13510 | ASAH1_HUMAN | ASAH1 | 395 | ||
A0A1B0GVA3 | A0A1B0GVA3_HUMAN | ASAH1 | 110 | ||
A0A1B0GVA8 | A0A1B0GVA8_HUMAN | ASAH1 | 67 | ||
A0A1B0GVC9 | A0A1B0GVC9_HUMAN | ASAH1 | 187 | ||
A0A1B0GUW4 | A0A1B0GUW4_HUMAN | ASAH1 | 368 | ||
A0A1B0GV88 | A0A1B0GV88_HUMAN | ASAH1 | 62 | ||
A0A1B0GV95 | A0A1B0GV95_HUMAN | ASAH1 | 140 | ||
A0A1B0GUP1 | A0A1B0GUP1_HUMAN | ASAH1 | 74 | ||
A0A1B0GV06 | A0A1B0GV06_HUMAN | ASAH1 | 200 | ||
A0A1B0GUQ5 | A0A1B0GUQ5_HUMAN | ASAH1 | 59 | ||
A0A1B0GUE3 | A0A1B0GUE3_HUMAN | ASAH1 | 330 | ||
A0A1B0GUG1 | A0A1B0GUG1_HUMAN | ASAH1 | 366 | ||
A0A1B0GUH5 | A0A1B0GUH5_HUMAN | ASAH1 | 393 | ||
A0A1B0GTZ5 | A0A1B0GTZ5_HUMAN | ASAH1 | 386 | ||
A0A1B0GUJ2 | A0A1B0GUJ2_HUMAN | ASAH1 | 72 | ||
A0A1B0GUJ3 | A0A1B0GUJ3_HUMAN | ASAH1 | 151 | ||
A0A1B0GUA4 | A0A1B0GUA4_HUMAN | ASAH1 | 375 | ||
A0A1B0GUB3 | A0A1B0GUB3_HUMAN | ASAH1 | 246 | ||
A0A1B0GTQ7 | A0A1B0GTQ7_HUMAN | ASAH1 | 56 | ||
A0A1B0GU62 | A0A1B0GU62_HUMAN | ASAH1 | 185 | ||
A0A1B0GU70 | A0A1B0GU70_HUMAN | ASAH1 | 31 | ||
A0A1B0GTX9 | A0A1B0GTX9_HUMAN | ASAH1 | 71 | ||
A0A1B0GTM3 | A0A1B0GTM3_HUMAN | ASAH1 | 376 | ||
A0A1B0GU06 | A0A1B0GU06_HUMAN | ASAH1 | 191 | ||
A0A1B0GTA6 | A0A1B0GTA6_HUMAN | ASAH1 | 81 | ||
A0A1B0GTP7 | A0A1B0GTP7_HUMAN | ASAH1 | 288 | ||
A0A1B0GTD4 | A0A1B0GTD4_HUMAN | ASAH1 | 42 | ||
A0A1B0GWC9 | A0A1B0GWC9_HUMAN | ASAH1 | 58 | ||
A0A1B0GVY5 | A0A1B0GVY5_HUMAN | ASAH1 | 49 | ||
A0A1B0GW30 | A0A1B0GW30_HUMAN | ASAH1 | 75 | ||
A0A1B0GW48 | A0A1B0GW48_HUMAN | ASAH1 | 173 | ||
A0A1B0GW68 | A0A1B0GW68_HUMAN | ASAH1 | 374 | ||
A0A1B0GVE7 | A0A1B0GVE7_HUMAN | ASAH1 | 184 | ||
A0A1B0GW66 | A0A1B0GW66_HUMAN | ASAH1 | 125 | ||
A0A1B0GVJ1 | A0A1B0GVJ1_HUMAN | ASAH1 | 175 | ||
A0A1B0GVL2 | A0A1B0GVL2_HUMAN | ASAH1 | 97 | ||
E7EMM4 | E7EMM4_HUMAN | ASAH1 | 370 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC124242 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KC877215 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |