A0A1B0GUS3 · A0A1B0GUS3_HUMAN

  • Protein
    Voltage-dependent P/Q-type calcium channel subunit alpha
  • Gene
    CACNA1A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents.

Catalytic activity

Features

Showing features for binding site.

124952004006008001,0001,2001,4001,6001,8002,0002,2002,400
TypeIDPosition(s)Description
Binding site318Ca2+ (UniProtKB | ChEBI)
Binding site668Ca2+ (UniProtKB | ChEBI)
Binding site1460Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent P/Q-type calcium channel subunit alpha

Gene names

    • Name
      CACNA1A

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1B0GUS3

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane102-119Helical
Transmembrane139-159Helical
Transmembrane222-245Helical
Transmembrane337-359Helical
Transmembrane488-507Helical
Transmembrane519-539Helical
Transmembrane614-636Helical
Transmembrane690-714Helical
Transmembrane1243-1262Helical
Transmembrane1282-1303Helical
Transmembrane1315-1332Helical
Transmembrane1377-1399Helical
Transmembrane1489-1514Helical
Transmembrane1570-1588Helical
Transmembrane1600-1623Helical
Transmembrane1691-1709Helical
Transmembrane1787-1811Helical

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 908 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for glycosylation, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Glycosylation283UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)750PRIDEPhosphoserine
Modified residue (large scale data)2108PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for coiled coil, region, compositional bias, domain.

TypeIDPosition(s)Description
Coiled coil710-746
Region819-1221Disordered
Compositional bias828-843Polar residues
Compositional bias853-875Basic and acidic residues
Compositional bias894-911Basic and acidic residues
Compositional bias918-1034Basic and acidic residues
Compositional bias1037-1054Polar residues
Compositional bias1115-1129Polar residues
Compositional bias1140-1162Polar residues
Compositional bias1193-1215Basic and acidic residues
Domain1948-1982Voltage-dependent calcium channel alpha-1 subunit IQ
Region1989-2032Disordered
Compositional bias2044-2067Polar residues
Region2044-2495Disordered
Compositional bias2098-2112Polar residues
Compositional bias2123-2142Basic and acidic residues
Compositional bias2193-2210Basic residues
Compositional bias2211-2247Basic and acidic residues
Compositional bias2248-2285Polar residues
Compositional bias2298-2319Polar residues
Compositional bias2478-2495Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,495
  • Mass (Da)
    281,200
  • Last updated
    2016-10-05 v1
  • Checksum
    EA547DEED3FEDA2B
MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAENQTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHGRRLPNGYYPAHGLARPRGPGSRKGLHEPYSESDDDWC

Computationally mapped potential isoform sequences

There are 23 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
O00555CAC1A_HUMANCACNA1A2506
B5TYJ1B5TYJ1_HUMANCACNA1A2263
A0AAQ5BGX1A0AAQ5BGX1_HUMANCACNA1A184
A0AAQ5BGX9A0AAQ5BGX9_HUMANCACNA1A1662
K7EIF8K7EIF8_HUMANCACNA1A89
A0A1B0GUM7A0A1B0GUM7_HUMANCACNA1A2165
A0A1B0GUP3A0A1B0GUP3_HUMANCACNA1A1867
A0A1B0GUE5A0A1B0GUE5_HUMANCACNA1A1664
A0A1B0GU74A0A1B0GU74_HUMANCACNA1A2302
A0A1B0GTW2A0A1B0GTW2_HUMANCACNA1A2460
A0A1B0GU81A0A1B0GU81_HUMANCACNA1A2507
A0A1B0GTI4A0A1B0GTI4_HUMANCACNA1A2262
A0A1B0GTN7A0A1B0GTN7_HUMANCACNA1A2507
A0A1B0GTG6A0A1B0GTG6_HUMANCACNA1A212
A0A1B0GVX1A0A1B0GVX1_HUMANCACNA1A2508
A0A590UJK2A0A590UJK2_HUMANCACNA1A2328
A0A1C7CYY9A0A1C7CYY9_HUMANCACNA1A2508
A0A384DVW2A0A384DVW2_HUMANCACNA1A2261
K7EKF7K7EKF7_HUMANCACNA1A2496
K7EQ95K7EQ95_HUMANCACNA1A2494
I3L2V5I3L2V5_HUMANCACNA1A108
I3L391I3L391_HUMANCACNA1A1667
A0A087WW63A0A087WW63_HUMANCACNA1A2512

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias828-843Polar residues
Compositional bias853-875Basic and acidic residues
Compositional bias894-911Basic and acidic residues
Compositional bias918-1034Basic and acidic residues
Compositional bias1037-1054Polar residues
Compositional bias1115-1129Polar residues
Compositional bias1140-1162Polar residues
Compositional bias1193-1215Basic and acidic residues
Compositional bias2044-2067Polar residues
Compositional bias2098-2112Polar residues
Compositional bias2123-2142Basic and acidic residues
Compositional bias2193-2210Basic residues
Compositional bias2211-2247Basic and acidic residues
Compositional bias2248-2285Polar residues
Compositional bias2298-2319Polar residues
Compositional bias2478-2495Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC005305
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC005513
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC011446
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC022436
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC026805
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC093062
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC098781
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC124224
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456505
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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