A0A1B0GUN6 · A0A1B0GUN6_HUMAN
- ProteinVoltage-dependent L-type calcium channel subunit alpha
- GeneCACNA1D
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2146 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent L-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1B0GUN6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 130-147 | Helical | ||||
Sequence: IFILLAIFANCVALAIYI | ||||||
Transmembrane | 167-187 | Helical | ||||
Sequence: AFLIIFTVETFLKIIAYGLLL | ||||||
Transmembrane | 199-218 | Helical | ||||
Sequence: LLDFVIVIVGLFSVILEQLT | ||||||
Transmembrane | 271-294 | Helical | ||||
Sequence: LLHIALLVLFVIIIYAIIGLELFI | ||||||
Transmembrane | 350-371 | Helical | ||||
Sequence: FAFAMLTVFQCITMEGWTDVLY | ||||||
Transmembrane | 383-405 | Helical | ||||
Sequence: WVYFVSLIILGSFFVLNLVLGVL | ||||||
Transmembrane | 523-541 | Helical | ||||
Sequence: VTFYWLVIVLVFLNTLTIS | ||||||
Transmembrane | 561-584 | Helical | ||||
Sequence: VLLALFTCEMLVKMYSLGLQAYFV | ||||||
Transmembrane | 653-672 | Helical | ||||
Sequence: LLLLLFLFIIIFSLLGMQLF | ||||||
Transmembrane | 725-752 | Helical | ||||
Sequence: GMIVCIYFIILFICGNYILLNVFLAIAV | ||||||
Transmembrane | 887-905 | Helical | ||||
Sequence: IFTNLILVFIMLSSAALAA | ||||||
Transmembrane | 925-945 | Helical | ||||
Sequence: AFTAIFTVEILLKMTTFGAFL | ||||||
Transmembrane | 957-983 | Helical | ||||
Sequence: LLDMLVVGVSLVSFGIQSSAISVVKIL | ||||||
Transmembrane | 1003-1033 | Helical | ||||
Sequence: HVVQCVFVAIRTIGNIMIVTTLLQFMFACIG | ||||||
Transmembrane | 1130-1155 | Helical | ||||
Sequence: IFFIIYIIIVAFFMMNIFVGFVIVTF | ||||||
Transmembrane | 1209-1227 | Helical | ||||
Sequence: YMMFVLIMLNTLCLAMQHY | ||||||
Transmembrane | 1239-1259 | Helical | ||||
Sequence: ILNMVFTGVFTVEMVLKVIAF | ||||||
Transmembrane | 1334-1352 | Helical | ||||
Sequence: ALPYVALLIAMLFFIYAVI | ||||||
Transmembrane | 1426-1449 | Helical | ||||
Sequence: IVYFISFYMLCAFLIINLFVAVIM |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,093 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Glycosylation | 329 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-21 | Disordered | ||||
Sequence: MMMMMMMKKMQHQRQQQADHA | ||||||
Region | 30-49 | Disordered | ||||
Sequence: TRLPLSGEGPTSQPNSSKQT | ||||||
Compositional bias | 35-49 | Polar residues | ||||
Sequence: SGEGPTSQPNSSKQT | ||||||
Region | 64-100 | Disordered | ||||
Sequence: KAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNS | ||||||
Region | 449-482 | Disordered | ||||
Sequence: DPENEEEGGEEGKRNTSMPTSETESVNTENVSGE | ||||||
Compositional bias | 462-482 | Polar residues | ||||
Sequence: RNTSMPTSETESVNTENVSGE | ||||||
Compositional bias | 766-788 | Basic and acidic residues | ||||
Sequence: KEEAEEKERKKIARKESLENKKN | ||||||
Region | 766-850 | Disordered | ||||
Sequence: KEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISE | ||||||
Compositional bias | 803-822 | Basic and acidic residues | ||||
Sequence: VTIDDYREEDEDKDPYPPCD | ||||||
Compositional bias | 823-838 | Acidic residues | ||||
Sequence: VPVGEEEEEEEEDEPE | ||||||
Domain | 1583-1617 | Voltage-dependent calcium channel alpha-1 subunit IQ | ||||
Sequence: DDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYP | ||||||
Region | 1644-1663 | Disordered | ||||
Sequence: SCDLQDDEPEETKREEEDDV | ||||||
Region | 1669-1789 | Disordered | ||||
Sequence: ALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRT | ||||||
Compositional bias | 1682-1697 | Polar residues | ||||
Sequence: RRDSLQQTNTTHRPLH | ||||||
Compositional bias | 1722-1751 | Polar residues | ||||
Sequence: CHNHHNHNSIGKQVPTSTNANLNNANMSKA | ||||||
Compositional bias | 1767-1789 | Basic and acidic residues | ||||
Sequence: ENGHHSSHKHDREPQRRSSVKRT | ||||||
Region | 1857-1904 | Disordered | ||||
Sequence: PGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHR | ||||||
Compositional bias | 1860-1893 | Basic and acidic residues | ||||
Sequence: NIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRR | ||||||
Region | 2093-2137 | Disordered | ||||
Sequence: NGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLA |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,146
- Mass (Da)243,705
- Last updated2016-10-05 v1
- ChecksumFE9180FDE7745CC5
Computationally mapped potential isoform sequences
There are 14 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q01668 | CAC1D_HUMAN | CACNA1D | 2161 | ||
A0A1B0GUH2 | A0A1B0GUH2_HUMAN | CACNA1D | 297 | ||
A0A1B0GUB6 | A0A1B0GUB6_HUMAN | CACNA1D | 1647 | ||
A0A1B0GU49 | A0A1B0GU49_HUMAN | CACNA1D | 72 | ||
A0A1B0GTN0 | A0A1B0GTN0_HUMAN | CACNA1D | 2170 | ||
A0A1B0GTP8 | A0A1B0GTP8_HUMAN | CACNA1D | 490 | ||
A0A1B0GWE1 | A0A1B0GWE1_HUMAN | CACNA1D | 1625 | ||
A0A1B0GWF7 | A0A1B0GWF7_HUMAN | CACNA1D | 284 | ||
A0A1B0GW98 | A0A1B0GW98_HUMAN | CACNA1D | 453 | ||
H0Y879 | H0Y879_HUMAN | CACNA1D | 2181 | ||
A0A1B0GVI2 | A0A1B0GVI2_HUMAN | CACNA1D | 223 | ||
A0A1W2PQ56 | A0A1W2PQ56_HUMAN | CACNA1D | 1643 | ||
H7C4S8 | H7C4S8_HUMAN | CACNA1D | 264 | ||
A0A5F9Z6M3 | A0A5F9Z6M3_HUMAN | CACNA1D | 710 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 35-49 | Polar residues | ||||
Sequence: SGEGPTSQPNSSKQT | ||||||
Compositional bias | 462-482 | Polar residues | ||||
Sequence: RNTSMPTSETESVNTENVSGE | ||||||
Compositional bias | 766-788 | Basic and acidic residues | ||||
Sequence: KEEAEEKERKKIARKESLENKKN | ||||||
Compositional bias | 803-822 | Basic and acidic residues | ||||
Sequence: VTIDDYREEDEDKDPYPPCD | ||||||
Compositional bias | 823-838 | Acidic residues | ||||
Sequence: VPVGEEEEEEEEDEPE | ||||||
Compositional bias | 1682-1697 | Polar residues | ||||
Sequence: RRDSLQQTNTTHRPLH | ||||||
Compositional bias | 1722-1751 | Polar residues | ||||
Sequence: CHNHHNHNSIGKQVPTSTNANLNNANMSKA | ||||||
Compositional bias | 1767-1789 | Basic and acidic residues | ||||
Sequence: ENGHHSSHKHDREPQRRSSVKRT | ||||||
Compositional bias | 1860-1893 | Basic and acidic residues | ||||
Sequence: NIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC005905 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC012467 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC024149 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC092035 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC112218 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC132810 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |