A0A1B0GTZ5 · A0A1B0GTZ5_HUMAN
- ProteinAcid ceramidase
- GeneASAH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids386 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine
Pathway
Lipid metabolism; sphingolipid metabolism.
Sphingolipid metabolism.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | lysosome | |
Molecular Function | ceramidase activity | |
Molecular Function | fatty acid amide hydrolase activity | |
Molecular Function | N-acylsphingosine amidohydrolase activity | |
Biological Process | fatty acid metabolic process | |
Biological Process | sphingolipid metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAcid ceramidase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1B0GTZ5
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 649 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Heterodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 61-123 | Acid ceramidase N-terminal | ||||
Sequence: GAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGN | ||||||
Domain | 144-375 | Choloylglycine hydrolase/NAAA C-terminal | ||||
Sequence: GHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETY |
Sequence similarities
Belongs to the acid ceramidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length386
- Mass (Da)43,640
- Last updated2016-10-05 v1
- ChecksumADC4DF2CF9F70BF2
Computationally mapped potential isoform sequences
There are 37 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q13510 | ASAH1_HUMAN | ASAH1 | 395 | ||
A0A1B0GVA3 | A0A1B0GVA3_HUMAN | ASAH1 | 110 | ||
A0A1B0GVA8 | A0A1B0GVA8_HUMAN | ASAH1 | 67 | ||
A0A1B0GVC9 | A0A1B0GVC9_HUMAN | ASAH1 | 187 | ||
A0A1B0GUW4 | A0A1B0GUW4_HUMAN | ASAH1 | 368 | ||
A0A1B0GV88 | A0A1B0GV88_HUMAN | ASAH1 | 62 | ||
A0A1B0GV95 | A0A1B0GV95_HUMAN | ASAH1 | 140 | ||
A0A1B0GUP1 | A0A1B0GUP1_HUMAN | ASAH1 | 74 | ||
A0A1B0GV06 | A0A1B0GV06_HUMAN | ASAH1 | 200 | ||
A0A1B0GUQ5 | A0A1B0GUQ5_HUMAN | ASAH1 | 59 | ||
A0A1B0GUE3 | A0A1B0GUE3_HUMAN | ASAH1 | 330 | ||
A0A1B0GUG1 | A0A1B0GUG1_HUMAN | ASAH1 | 366 | ||
A0A1B0GUH5 | A0A1B0GUH5_HUMAN | ASAH1 | 393 | ||
A0A1B0GUJ2 | A0A1B0GUJ2_HUMAN | ASAH1 | 72 | ||
A0A1B0GUJ3 | A0A1B0GUJ3_HUMAN | ASAH1 | 151 | ||
A0A1B0GUA4 | A0A1B0GUA4_HUMAN | ASAH1 | 375 | ||
A0A1B0GUB3 | A0A1B0GUB3_HUMAN | ASAH1 | 246 | ||
A0A1B0GTQ7 | A0A1B0GTQ7_HUMAN | ASAH1 | 56 | ||
A0A1B0GU62 | A0A1B0GU62_HUMAN | ASAH1 | 185 | ||
A0A1B0GU70 | A0A1B0GU70_HUMAN | ASAH1 | 31 | ||
A0A1B0GTX9 | A0A1B0GTX9_HUMAN | ASAH1 | 71 | ||
A0A1B0GTM3 | A0A1B0GTM3_HUMAN | ASAH1 | 376 | ||
A0A1B0GU06 | A0A1B0GU06_HUMAN | ASAH1 | 191 | ||
A0A1B0GTA6 | A0A1B0GTA6_HUMAN | ASAH1 | 81 | ||
A0A1B0GTP7 | A0A1B0GTP7_HUMAN | ASAH1 | 288 | ||
A0A1B0GTD4 | A0A1B0GTD4_HUMAN | ASAH1 | 42 | ||
A0A1B0GWC9 | A0A1B0GWC9_HUMAN | ASAH1 | 58 | ||
A0A1B0GVY5 | A0A1B0GVY5_HUMAN | ASAH1 | 49 | ||
A0A1B0GW30 | A0A1B0GW30_HUMAN | ASAH1 | 75 | ||
A0A1B0GW48 | A0A1B0GW48_HUMAN | ASAH1 | 173 | ||
A0A1B0GW68 | A0A1B0GW68_HUMAN | ASAH1 | 374 | ||
A0A1B0GVE7 | A0A1B0GVE7_HUMAN | ASAH1 | 184 | ||
A0A1B0GW66 | A0A1B0GW66_HUMAN | ASAH1 | 125 | ||
A0A1B0GVG2 | A0A1B0GVG2_HUMAN | ASAH1 | 341 | ||
A0A1B0GVJ1 | A0A1B0GVJ1_HUMAN | ASAH1 | 175 | ||
A0A1B0GVL2 | A0A1B0GVL2_HUMAN | ASAH1 | 97 | ||
E7EMM4 | E7EMM4_HUMAN | ASAH1 | 370 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC124242 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KC877215 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |