A0A1B0GTZ5 · A0A1B0GTZ5_HUMAN

  • Protein
    Acid ceramidase
  • Gene
    ASAH1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Pathway

Lipid metabolism; sphingolipid metabolism.
Sphingolipid metabolism.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentlysosome
Molecular Functionceramidase activity
Molecular Functionfatty acid amide hydrolase activity
Molecular FunctionN-acylsphingosine amidohydrolase activity
Biological Processfatty acid metabolic process
Biological Processsphingolipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acid ceramidase
  • EC number

Gene names

    • Name
      ASAH1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1B0GTZ5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 649 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Heterodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain61-123Acid ceramidase N-terminal
Domain144-375Choloylglycine hydrolase/NAAA C-terminal

Sequence similarities

Belongs to the acid ceramidase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    386
  • Mass (Da)
    43,640
  • Last updated
    2016-10-05 v1
  • Checksum
    ADC4DF2CF9F70BF2
MNCCIGLGEKARGSHRASYPSLSALFTEASILGFGSFAVKAQWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW

Computationally mapped potential isoform sequences

There are 37 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q13510ASAH1_HUMANASAH1395
A0A1B0GVA3A0A1B0GVA3_HUMANASAH1110
A0A1B0GVA8A0A1B0GVA8_HUMANASAH167
A0A1B0GVC9A0A1B0GVC9_HUMANASAH1187
A0A1B0GUW4A0A1B0GUW4_HUMANASAH1368
A0A1B0GV88A0A1B0GV88_HUMANASAH162
A0A1B0GV95A0A1B0GV95_HUMANASAH1140
A0A1B0GUP1A0A1B0GUP1_HUMANASAH174
A0A1B0GV06A0A1B0GV06_HUMANASAH1200
A0A1B0GUQ5A0A1B0GUQ5_HUMANASAH159
A0A1B0GUE3A0A1B0GUE3_HUMANASAH1330
A0A1B0GUG1A0A1B0GUG1_HUMANASAH1366
A0A1B0GUH5A0A1B0GUH5_HUMANASAH1393
A0A1B0GUJ2A0A1B0GUJ2_HUMANASAH172
A0A1B0GUJ3A0A1B0GUJ3_HUMANASAH1151
A0A1B0GUA4A0A1B0GUA4_HUMANASAH1375
A0A1B0GUB3A0A1B0GUB3_HUMANASAH1246
A0A1B0GTQ7A0A1B0GTQ7_HUMANASAH156
A0A1B0GU62A0A1B0GU62_HUMANASAH1185
A0A1B0GU70A0A1B0GU70_HUMANASAH131
A0A1B0GTX9A0A1B0GTX9_HUMANASAH171
A0A1B0GTM3A0A1B0GTM3_HUMANASAH1376
A0A1B0GU06A0A1B0GU06_HUMANASAH1191
A0A1B0GTA6A0A1B0GTA6_HUMANASAH181
A0A1B0GTP7A0A1B0GTP7_HUMANASAH1288
A0A1B0GTD4A0A1B0GTD4_HUMANASAH142
A0A1B0GWC9A0A1B0GWC9_HUMANASAH158
A0A1B0GVY5A0A1B0GVY5_HUMANASAH149
A0A1B0GW30A0A1B0GW30_HUMANASAH175
A0A1B0GW48A0A1B0GW48_HUMANASAH1173
A0A1B0GW68A0A1B0GW68_HUMANASAH1374
A0A1B0GVE7A0A1B0GVE7_HUMANASAH1184
A0A1B0GW66A0A1B0GW66_HUMANASAH1125
A0A1B0GVG2A0A1B0GVG2_HUMANASAH1341
A0A1B0GVJ1A0A1B0GVJ1_HUMANASAH1175
A0A1B0GVL2A0A1B0GVL2_HUMANASAH197
E7EMM4E7EMM4_HUMANASAH1370

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC124242
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KC877215
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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