A0A1A9VJU3 · A0A1A9VJU3_GLOAU

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex I
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • TTRI
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Hippoboscoidea > Glossinidae > Glossina

Accessions

  • Primary accession
    A0A1A9VJU3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain329-374NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    417
  • Mass (Da)
    45,935
  • Last updated
    2016-10-05 v1
  • MD5 Checksum
    3416905817CEFD9C1C3CFCBE3FF55581
MLKEQDKIFTNLNGKETPLLKGAKKRGSWQKTKELLDLGSEKIIDEVKKSGLRGRGGAGFSTGLKWSFMPKNLPKAYLVVNADESEPGTCKDRDILRYEPHKLLEGILLTGKATSASVVYIYIRGEFYNEYLVLKKALEEAYKENLIGKNACKSGYDLDVFIHRGAGAYICGEETTQLESIEGKKGFPRMKPPFPAGVGLFGCPTTINNVETIAMVPDILNRGGEWFASLGKPNNTGTKIFCISGHVNNPCNVEEELGIPLRELIEKYAGGVRGGWDNLLAVIPGGSSVPLIPKSICDTIEMDFDSLRTAQSGLGTAAVIVMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWRIMKRMVAGDIKPDEIDKLLDLTTQIEGHTICALGDAAAWPIQGLIRHFRHIIKERAII

Genome annotation databases

Similar Proteins

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