A0A1A8YM78 · A0A1A8YM78_PLAOA

Function

function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Features

Showing features for active site, binding site.

124720406080100120140160180200220240
Type
IDPosition(s)Description
Active site13Nucleophile
Binding site13Mg2+ 1 (UniProtKB | ChEBI)
Active site15Proton donor/acceptor
Binding site15Mg2+ 1 (UniProtKB | ChEBI)
Binding site22alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site124alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site135alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site142alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site180alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site182alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site209Mg2+ 1 (UniProtKB | ChEBI)
Binding site221Mg2+ 1 (UniProtKB | ChEBI)
Binding site223Mg2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionphosphomannomutase activity
Biological ProcessGDP-mannose biosynthetic process
Biological Processmannose metabolic process
Biological Processprotein N-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomannomutase
  • EC number

Gene names

    • ORF names
      POVWA1_012950
      , POVWA2_081100

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A0A1A8YM78

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the eukaryotic PMM family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    247
  • Mass (Da)
    28,385
  • Last updated
    2016-10-05 v1
  • Checksum
    F1456285FD3271F1
MTMKGKNVFFLFDVDGTLTHSRKVIDSKMVDALLELKSKGKCTLGVVGGSDYKKIIEQIKDPGMFEFIFSENGVVAHKNNEQYFAESIVNFLGEDKLKELINYCLVYISNLDIPKKRGTFIELRNAILNISPIGRNCSQEERDEFCEYNNEKDILKKFRQDLIKRFGAFNLTFSIGGQISIDCFPTGWDKTFCLRHIEGFFSKIYFLGDKTEEGGNDYEIYNDKRVQGYSVSCPDDTIEVIKRFLDV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FLRD01000041
EMBL· GenBank· DDBJ
SBT32613.1
EMBL· GenBank· DDBJ
Genomic DNA
FLRE01001976
EMBL· GenBank· DDBJ
SBT57698.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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