A0A1A8VU49 · A0A1A8VU49_9APIC
- ProteinEnolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids443 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (2R)-2-phosphoglycerate = H2O + phosphoenolpyruvateThis reaction proceeds in the forward and the backward directions.
Cofactor
Note: Mg2+ is required for catalysis and for stabilizing the dimer.
Pathway
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 163 | substrate | ||||
Sequence: H | ||||||
Binding site | 172 | substrate | ||||
Sequence: E | ||||||
Active site | 215 | Proton donor | ||||
Sequence: E | ||||||
Binding site | 250 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 301 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 301 | substrate | ||||
Sequence: E | ||||||
Binding site | 328 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 328 | substrate | ||||
Sequence: D | ||||||
Active site | 353 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 380-383 | substrate | ||||
Sequence: SHRS | ||||||
Binding site | 404 | substrate | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | cytoskeleton | |
Cellular Component | nucleus | |
Cellular Component | phosphopyruvate hydratase complex | |
Cellular Component | plasma membrane | |
Cellular Component | vacuole | |
Molecular Function | magnesium ion binding | |
Molecular Function | phosphopyruvate hydratase activity | |
Biological Process | glycolytic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEnolase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)
Accessions
- Primary accessionA0A1A8VU49
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-137 | Enolase N-terminal | ||||
Sequence: DSRGNPTVEVDLETNVGIFRAAVPSGASTGIYEALELRDNDKTRYLGKGVQQAIKNINEKIAPKLIGLDCRDQKKIDNMMVEELDGSKNEWGWSKSKLGANAILAVSMAICRAGAAANNVSLYKYL | ||||||
Domain | 147-441 | Enolase C-terminal TIM barrel | ||||
Sequence: NMVLPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEALRYGAEVYHTLKSEIKKKYGIDATNVGDEGGFAPNILNANEALDLLVSAIKGAGYEGKVKIAMDVAASEFYNSENKTYDLDFKTPNNDKSLVKTGDELVKLYIDLVKKYPIVSIEDPFDQDDWEHYAKLTEAIGKDVQIVGDDLLVTNPTRITKALEKKACNALLLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKYNQLLRIEESLGSSALFAGEKFKLQ |
Sequence similarities
Belongs to the enolase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)48,340
- Last updated2016-10-05 v1
- Checksum47518F78B27880BB
Keywords
- Technical term