A0A1A8VMS2 · A0A1A8VMS2_9APIC
- ProteinN(6)-L-threonylcarbamoyladenine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids572 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- adenosine37 in tRNA + L-threonylcarbamoyladenylate = AMP + H+ + N6-L-threonylcarbamoyladenosine37 in tRNA
Cofactor
Note: Binds 1 divalent metal cation per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 120 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 124 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 141 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 175 | substrate | ||||
Sequence: D | ||||||
Binding site | 190 | substrate | ||||
Sequence: G | ||||||
Binding site | 194 | substrate | ||||
Sequence: E | ||||||
Binding site | 501 | substrate | ||||
Sequence: N | ||||||
Binding site | 529 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | EKC/KEOPS complex | |
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | N(6)-L-threonylcarbamoyladenine synthase activity | |
Biological Process | tRNA threonylcarbamoyladenosine modification |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameN(6)-L-threonylcarbamoyladenine synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)
Accessions
- Primary accessionA0A1A8VMS2
Proteomes
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 40-201 | Gcp-like | ||||
Sequence: RRTYVSEIGCGFIPREINAHHKFYIIDMIKDCLQKLKIKITDITLICYTRGPGIGSALYIAYNICKIFSLLFNIPVIGVNHCIAHIEMGIFITRLKKPIILYVSGSNTQIIYFNDHKKRYEIIGETLDIAIGNVIDRSARILRISNSPSPGYNVEMWARKKY | ||||||
Compositional bias | 314-351 | Basic and acidic residues | ||||
Sequence: KEKGVAEEGKKKKKKHCSQQKGDHAEMERVESAENSSD | ||||||
Region | 314-381 | Disordered | ||||
Sequence: KEKGVAEEGKKKKKKHCSQQKGDHAEMERVESAENSSDENVNKDTSANANSNTTANTSKRAQDTGGFL | ||||||
Compositional bias | 352-376 | Polar residues | ||||
Sequence: ENVNKDTSANANSNTTANTSKRAQD | ||||||
Region | 426-454 | Disordered | ||||
Sequence: SEDVNGESALSGDPDDSGEISNRGETSKL | ||||||
Domain | 462-536 | Gcp-like | ||||
Sequence: IQICYSLQHHIFSMLIEITERAISFTDSKEVIIVGGVGCNLFLQNMMKKMARQKNIKIGFMDHSYCVDNGAMIAY |
Sequence similarities
Belongs to the KAE1 / TsaD family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length572
- Mass (Da)65,388
- Last updated2016-10-05 v1
- ChecksumB83A9178EC159069
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 314-351 | Basic and acidic residues | ||||
Sequence: KEKGVAEEGKKKKKKHCSQQKGDHAEMERVESAENSSD | ||||||
Compositional bias | 352-376 | Polar residues | ||||
Sequence: ENVNKDTSANANSNTTANTSKRAQD |
Keywords
- Technical term