A0A1A8VK87 · A0A1A8VK87_9APIC

Function

function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site14ATP (UniProtKB | ChEBI)
Binding site16ATP (UniProtKB | ChEBI)
Binding site17ATP (UniProtKB | ChEBI)
Binding site18ATP (UniProtKB | ChEBI)
Binding site19ATP (UniProtKB | ChEBI)
Binding site141ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase isoenzyme 6 homolog
  • EC number
  • Short names
    AK6
  • Alternative names
    • Dual activity adenylate kinase/ATPase
      (AK/ATPase
      )

Gene names

    • ORF names
      POVCU1_001920
      , POVCU2_0002120

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A0A1A8VK87

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region62-85NMPbind
Region140-150LID

Sequence similarities

Belongs to the adenylate kinase family. AK6 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    207
  • Mass (Da)
    24,177
  • Last updated
    2016-10-05 v1
  • Checksum
    1D7AF9C410E9F5ED
MKRLPNIIVTGVPGVGKTTLCEELVSLINKELIGIKEDTNVEKNTRETIKEATEVLAMVHLNLSKVIKEERLYEEYDDELDATIYDDDMVNEKLTSLEVEKGGFIFDFHDINFIIHKKKFIDHIFLLTASTNSLYDRLEKRNYTLEKIKNNIECEIFQTIKEDILEHFDDPTIFHELENNTLQQHEDNLDFVKKWVLANFRGVEKSG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FLQU01000025
EMBL· GenBank· DDBJ
SBS80018.1
EMBL· GenBank· DDBJ
Genomic DNA
FLQV01000043
EMBL· GenBank· DDBJ
SBS80609.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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