A0A198WP26 · A0A198WP26_MORCA

Function

function

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site54Part of a proton relay during catalysis
Binding site55pyruvate (UniProtKB | ChEBI)
Site59L-lysine inhibitor binding; via carbonyl oxygen
Site90L-lysine inhibitor binding
Site94L-lysine inhibitor binding
Site116L-lysine inhibitor binding
Site117Part of a proton relay during catalysis
Active site143Proton donor/acceptor
Active site171Schiff-base intermediate with substrate
Binding site213pyruvate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate synthase activity
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate synthase
  • EC number
  • Short names
    HTPA synthase

Gene names

    • Name
      dapA
    • ORF names
      D6D77_02980

Organism names

Accessions

  • Primary accession
    A0A198WP26

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer; dimer of dimers.

Family & Domains

Sequence similarities

Belongs to the DapA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    301
  • Mass (Da)
    32,702
  • Last updated
    2016-10-05 v1
  • Checksum
    7F04358BAD94954C
MTDAYQQIKSTLKGVMTALVTPMKPDGSVDYDTLAHLIDWQINEGVHALVAVGTTGEAATLAIDEHIDVIRFFVKQVAGRIPVIAGTGANSTREAIDLTMAAKAAGADFALLVVPYYNKPTQEGMYQHFKAVATAVDIPQIVYNVPGRTVVDMCEDTVSRLADIDNIVAIKDATGNLERGISLIRRVGERMVVLSGDDPTALELIKYGSKGDISVTSNIAPKAMSQAFGLALEGRFEEAYQIHDTIVHLHRDLFIESSPQPVKYALNKMGKIGTGIRLPMVWLAEHYHETIDNSLKKAGLI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QZGP01000002
EMBL· GenBank· DDBJ
RKL89996.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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