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A0A197K5U9 · A0A197K5U9_9FUNG

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      K457DRAFT_134672

Organism names

  • Taxonomic identifier
  • Strain
    • AG-77
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mortierellomycotina > Mortierellomycetes > Mortierellales > Mortierellaceae > Linnemannia

Accessions

  • Primary accession
    A0A197K5U9

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane99-120Helical
Transmembrane140-161Helical
Transmembrane173-191Helical
Transmembrane197-216Helical
Transmembrane228-250Helical
Transmembrane262-287Helical
Transmembrane316-339Helical
Transmembrane359-377Helical
Transmembrane389-409Helical
Transmembrane421-441Helical
Transmembrane513-534Helical
Transmembrane546-562Helical
Transmembrane717-738Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias1-23Polar residues
Region1-62Disordered
Compositional bias24-48Basic and acidic residues
Compositional bias70-87Basic and acidic residues
Region70-89Disordered
Compositional bias563-577Basic residues
Region563-583Disordered
Compositional bias630-650Polar residues
Region630-700Disordered
Compositional bias674-689Acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    739
  • Mass (Da)
    81,995
  • Last updated
    2016-10-05 v1
  • MD5 Checksum
    C3749A6831FDB1DD9D2153BF09B4ED25
MSDSRIDYQPLSTRGQDSPALSHSSNDEAKREHNSHGHDDDDEYDAIHATESQGLVSTSSDRDFIEHHRQQRLLEGEENEDTGSGLASKKDPKVAAAEWAVKVQAFSCAALLGISTHFTIHMTGPLKDVLKENMDISNTQFSLLQSSLTLFPTLTPLIGGLLIERYGTGPSSIVFTTIVIAGQAIVILGCWTYSVKIMILGYCLFGLGAAPITIIQETIWVRHFKKDGLALVLALGLTSGKLAGFLALATSVPLTTLPPFGFVTPFFVSLIISAIAWVMNIIFLTLLEKPKEGTDAMTKITILLKAKRTNLGWREVYGFSTMFWTLLTISFLVGASWNPFMHQSSNIVKHRYGLDDEQAAWQASIILAVPLIIYPFLGTFIDHAGKRAWMLLVTAGLLIGTHVLLLIPYSSIPIPPTVPMLLFALSLSLGTLSIVTSMPVLTKHVPTGLGLHRSIDNIGATLFGTVSGMMQDFSGVTGPDGETDTENFFDRLYHHFFPVHVDEALQEKEDTRLLGLFLAVAILTFIACSIFVWGDYHWTDGEGGKTGLVNGVYGRTPAAVLARHRRRSRRRREQRNRRRSHEVLEAMTLEPIFELDDEQDAEEVTMTEISAHNSHRQRDRDEQHEYHLSNQLPATPGSQMHESETDSPSSGRGLLLGDDRRRQRGGEFLSTPDGSEGESDDENDEDSEDENGERRFGVRIESGDDEVPRWKKTQAHFWIMVWSILLLTSWVVFGIGVAK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-23Polar residues
Compositional bias24-48Basic and acidic residues
Compositional bias70-87Basic and acidic residues
Compositional bias563-577Basic residues
Compositional bias630-650Polar residues
Compositional bias674-689Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV442022
EMBL· GenBank· DDBJ
OAQ33032.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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