A0A183L9F5 · A0A183L9F5_9TREM
- ProteinDNA replication ATP-dependent helicase/nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1346 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | 5'-flap endonuclease activity | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | single-stranded DNA helicase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication, Okazaki fragment processing | |
Biological Process | replication fork reversal |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA replication ATP-dependent helicase/nuclease
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma
Accessions
- Primary accessionA0A183L9F5
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 325-556 | DNA replication factor Dna2 N-terminal | ||||
Sequence: DNRTKINVILRDSWFDTPIRIKDAINIIPNVYGDIKSPVYNNSTLIISDDNNNKTQNDCAALCLNPDYLLPTTKVVSSLNCLRRVVLEQFWVTDGGYREDNEITVIDSNQTYNSQCDVMLTGSLVHELFQKIISRHNIQREDVLQIVSGLIYRPSVVLQMYASGIEPKSLFTKLEEFIPKIFDWTQTHCIQHLPSRNSVTTINQVKIEDVVAIEENIWSNRLGLKGKIDSTL | ||||||
Domain | 924-1024 | DNA2/NAM7 helicase helicase | ||||
Sequence: LNINQRTAILQTLFSQNYILIKGYPGSGKTETLVALLRVLILLKKRILVTAHTHSAVDNLLLRLCKTGENRVIRLGQMDRILPDLLNYSFEYKLNKFLKSD | ||||||
Domain | 1033-1121 | DNA2/NAM7 helicase helicase | ||||
Sequence: DYINNIMANTVVVGCTALSASGGNDLRHSALTYQKFDVVLIDEASQLMFPTTLGPLLCLAEEQQSLDCIKCCRFVLVGDPYQLPPLVRS | ||||||
Domain | 1152-1326 | DNA2/NAM7 helicase-like C-terminal | ||||
Sequence: SSMDFSKKGYVTELTIQYRMNSKIMALSNQLTYKNKMSCANSCVSQATLKLNPNIVSDEISDKLPLWIKRVNSPLLSDSVLLLDTKMLDCYSLSENESRTSNSNPIEAQLILYIIKRIHRVFLLEMEDIGVITPYRAQVYLLKNMMKENSFGSIEVNTVDQFQGRDKRLIFLSLT |
Sequence similarities
Belongs to the DNA2/NAM7 helicase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,346
- Mass (Da)152,345
- Last updated2016-09-07 v1
- Checksum252037CA458B5BB0
Keywords
- Technical term